Document Detail


Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9.
MedLine Citation:
PMID:  10804168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of the homeobox gene Uncx4.1 in the somite is restricted to the caudal half of the newly formed somite and sclerotome. Here we show that mice with a targeted mutation of the Uncx4.1 gene exhibit defects in the axial skeleton and ribs. In the absence of Uncx4.1, pedicles of the neural arches and proximal ribs are not formed. In addition, dorsal root ganglia are disorganized. Histological and marker analysis revealed that Uncx4.1 is not necessary for somite segmentation. It is required to maintain the condensation of the caudal half-sclerotome, from which the missing skeletal elements are derived. The loss of proximal ribs in Pax1/Pax9 double mutants and the data presented here argue for a role of Uncx4.1 upstream of Pax9 in the caudolateral sclerotome. Our results further indicate that Uncx4.1 may be involved in the differential cell adhesion properties of the somite.
Authors:
A Mansouri; A K Voss; T Thomas; Y Yokota; P Gruss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  127     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-14     Completed Date:  2000-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2251-8     Citation Subset:  IM    
Affiliation:
Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D-37077 Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axis / embryology*
Cell Adhesion / physiology
Cell Differentiation
DNA-Binding Proteins / genetics*
Ganglia, Spinal / abnormalities,  embryology
Homeodomain Proteins / genetics,  physiology*
Mice
PAX9 Transcription Factor
Ribs / embryology*
Somites
Spinal Nerves / abnormalities,  embryology
Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Homeodomain Proteins; 0/PAX9 Transcription Factor; 0/Transcription Factors; 0/Uncx4.1 protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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