| Uncrossed and crossed inhibition in the inferior colliculus of the cat: a combined 2-deoxyglucose and electrophysiological study. | |
| | |
MedLine Citation:
|
PMID: 4020421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The cat inferior colliculus (IC) was studied with 2-deoxyglucose (2-DG). By presenting high-frequency tone bursts to one ear and white noise bursts simultaneously to the other, a band of reduced or inhibitory labeling was revealed in the central nucleus (ICC) of the IC ipsilateral to the ear receiving the tone bursts. It was concluded that this ipsilateral inhibition might be related to the organization of excitatory/inhibitory units in ICC. In the opposite ICC, narrow bands of increased labeling were seen. In some animals, the positions of single units were marked, and tone frequencies were presented under 2-DG, which were the same as these units' characteristic frequencies (CFs). The positions of the units coincided with the position of the inhibitory bands, indicating that they were functional isofrequency-inhibitory contours. Unlike higher auditory centers, the binaural inhibitory areas were in register with and not orthogonal to the excitatory isofrequency contours. The inhibitory contours were generally larger than the excitatory contours and became even larger in more caudal sections. Both the inhibitory and excitatory contours extended into dorsal cortex areas of IC. In two other cats, high-frequency tone bursts and white noise bursts were presented to the same ear, and both a band of increased and a band of reduced labelling were found in the IC contralateral to this ear. The inhibitory band was always lateral to the excitatory band and was often smaller. They did not become larger in more caudal sections. The position of a unit in one cat was marked by pontamine sky blue, and the position of the unit coincided with the position of the excitatory band. It was concluded that this lateral inhibitory band represents high-frequency inhibitory sidebands of cells with CFs lower than the stimulating tone. It is concluded that the 2-DG method might reveal hitherto unknown inhibitory systems if stimuli could be combined with diffuse stimuli that raised the general background activity of sensory systems. |
| | |
Authors:
|
W R Webster; J Serviere; R Martin; M Brown |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 5 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1985 Jul |
Date Detail:
|
Created Date: 1985-08-26 Completed Date: 1985-08-26 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1820-32 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation Animals Cats Deoxyglucose Electrophysiology* Inferior Colliculi / anatomy & histology, physiology* Neural Inhibition* |
| Chemical | |
Reg. No./Substance:
|
154-17-6/Deoxyglucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of neuromuscular specificity in the grasshopper embryo: guidance of motoneuron growth co...
Next Document: Structure and expression of the egg-laying hormone gene family in Aplysia.