Document Detail

Uncovering selection bias in case-control studies using Bayesian post-stratification.
MedLine Citation:
PMID:  23303593     Owner:  NLM     Status:  MEDLINE    
Case-control studies are particularly prone to selection bias, which can affect odds ratio estimation. Approaches to discovering and adjusting for selection bias have been proposed in the literature using graphical and heuristic tools as well as more complex statistical methods. The approach we propose is based on a survey-weighting method termed Bayesian post-stratification and follows from the conditional independences that characterise selection bias. We use our approach to perform a selection bias sensitivity analysis by using ancillary data sources that describe the target case-control population to re-weight the odds ratio estimates obtained from the study. The method is applied to two case-control studies, the first investigating the association between exposure to electromagnetic fields and acute lymphoblastic leukaemia in children and the second investigating the association between maternal occupational exposure to hairspray and a congenital anomaly in male babies called hypospadias. In both case-control studies, our method showed that the odds ratios were only moderately sensitive to selection bias.
S Geneletti; N Best; M B Toledano; P Elliott; S Richardson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-10
Journal Detail:
Title:  Statistics in medicine     Volume:  32     ISSN:  1097-0258     ISO Abbreviation:  Stat Med     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-11     Completed Date:  2014-01-21     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2555-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
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MeSH Terms
Bayes Theorem*
Biostatistics / methods*
Case-Control Studies*
Electromagnetic Fields / adverse effects
Hair Preparations / adverse effects
Hypospadias / etiology
Infant, Newborn
Maternal Exposure / adverse effects
Occupational Exposure / adverse effects
Odds Ratio
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
Selection Bias*
Grant Support
G0801056//Medical Research Council; //Department of Health
Reg. No./Substance:
0/Hair Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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