| Uncovering residual effects of chronic sleep loss on human performance. | |
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MedLine Citation:
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PMID: 20371466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sleep loss leads to profound performance decrements. Yet many individuals believe they adapt to chronic sleep loss or that recovery requires only a single extended sleep episode. To evaluate this, we designed a protocol whereby the durations of sleep and wake episodes were increased to 10 and 32.85 hours, respectively, to yield a reduced sleep-to-wake ratio of 1:3.3. These sleep and wake episodes were distributed across all circadian phases, enabling measurement of the effects of acute and chronic sleep loss at different times of the circadian day and night. Despite recurrent acute and substantial chronic sleep loss, 10-hour sleep opportunities consistently restored vigilance task performance during the first several hours of wakefulness. However, chronic sleep loss markedly increased the rate of deterioration in performance across wakefulness, particularly during the circadian "night." Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences. |
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Authors:
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Daniel A Cohen; Wei Wang; James K Wyatt; Richard E Kronauer; Derk-Jan Dijk; Charles A Czeisler; Elizabeth B Klerman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Science translational medicine Volume: 2 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-06-21 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 14ra3 Citation Subset: IM |
Affiliation:
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Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Attention Circadian Rhythm Female Humans Male Models, Statistical Psychomotor Performance Reaction Time Sleep* Wakefulness* Work Schedule Tolerance |
| Grant Support | |
ID/Acronym/Agency:
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K02 HD045459/HD/NICHD NIH HHS; K02 HD045459-01/HD/NICHD NIH HHS; K02 HD045459-02/HD/NICHD NIH HHS; K02 HD045459-03/HD/NICHD NIH HHS; K02 HD045459-04/HD/NICHD NIH HHS; K02 HD045459-05/HD/NICHD NIH HHS; K02-HD045459/HD/NICHD NIH HHS; M01 RR002635/RR/NCRR NIH HHS; M01 RR002635-245573/RR/NCRR NIH HHS; M01-RR-02635/RR/NCRR NIH HHS; P01 AG009975/AG/NIA NIH HHS; P01-AG09975/AG/NIA NIH HHS; T32 HL007901/HL/NHLBI NIH HHS; T32-HL07901/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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