Document Detail


Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat.
MedLine Citation:
PMID:  17082369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phasic bursting in the hypoglossal nerve can be uncoupled from phrenic bursting by application of positive end-expired pressure (PEEP). We wished to determine whether similar uncoupling can also be induced in other respiratory-modulated upper airway (UAW) motor outputs. Discharge of the facial, hypoglossal, superior laryngeal, recurrent laryngeal, and phrenic nerves was recorded in anesthetized, ventilated rats during stepwise changes in PEEP with a normocapnic, hyperoxic background. Application of 3- to 6-cmH(2)O PEEP caused the onset inspiratory (I) UAW nerve bursting to precede the phrenic burst but did not uncouple bursting. In contrast, application of 9- to 12-cmH(2)O PEEP uncoupled UAW neurograms such that rhythmic bursting occurred during periods of phrenic quiescence. Single-fiber recording experiments were conducted to determine whether a specific population of UAW motoneurons is recruited during uncoupled bursting. The data indicate that expiratory-inspiratory (EI) motoneurons remained active, while I motoneurons did not fire during uncoupled UAW bursting. Finally, we examined the relationship between motoneuron discharge rate and PEEP during coupled UAW and phrenic bursting. EI discharge rate was linearly related to PEEP during preinspiration, but showed no relationship to PEEP during inspiration. Our results demonstrate that multiple UAW motor outputs can be uncoupled from phrenic bursting, and this response is associated with bursting of EI nerve fibers. The relationship between PEEP and EI motoneuron discharge rate differs during preinspiratory and I periods; this may indicate that bursting during these phases of the respiratory cycle is controlled by distinct neuronal outputs.
Authors:
Kun-Ze Lee; David D Fuller; Li-Chu Tung; I-Jung Lu; Li-Chi Ku; Ji-Chuu Hwang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-02
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-07     Completed Date:  2007-04-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  878-89     Citation Subset:  IM    
Affiliation:
Dept. of Life Science, National Taiwan Normal University, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Exhalation / physiology
Heart Rate / physiology
Inhalation / physiology
Male
Motor Activity / physiology*
Motor Neurons / physiology
Phrenic Nerve / physiology*
Positive-Pressure Respiration*
Rats
Rats, Wistar
Respiratory Physiological Phenomena*
Respiratory System / innervation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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