| Uncoupling proteins in heart failure. | |
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MedLine Citation:
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PMID: 18765077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of heart failure is associated with alterations in the expression of a wide variety of structural, signaling, and metabolic proteins. One such effect is the downregulation of uncoupling proteins in the setting of heart failure. This group of proteins regulates the mitochondrial membrane potential and therefore plays a role in mitochondrial energy metabolism as well as reactive oxygen species generation by the mitochondria. This review discusses the role of uncoupling proteins in regulating oxidant stress and implications with respect to the pathogenesis of heart failure and potential treatments. |
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Authors:
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Karl R Laskowski; Raymond R Russell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current heart failure reports Volume: 5 ISSN: 1546-9549 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-09-03 Completed Date: 2008-12-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
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Languages: eng Pagination: 75-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Disease Progression Down-Regulation Energy Metabolism / physiology Female Gene Expression Regulation Heart Failure / metabolism, physiopathology* Humans Ion Channels / genetics, metabolism* Male Mitochondria / metabolism Mitochondrial Proteins / genetics, metabolism* Oxidative Stress / physiology* RNA, Messenger / analysis Rats Reactive Oxygen Species / metabolism* Sensitivity and Specificity Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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HL077310/HL/NHLBI NIH HHS; R01 HL077310-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 0/Mitochondrial Proteins; 0/RNA, Messenger; 0/Reactive Oxygen Species; 0/mitochondrial uncoupling protein 2; 0/mitochondrial uncoupling protein 3 |
| Comments/Corrections | |
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