Document Detail


Uncoupling proteins in heart failure.
MedLine Citation:
PMID:  18765077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of heart failure is associated with alterations in the expression of a wide variety of structural, signaling, and metabolic proteins. One such effect is the downregulation of uncoupling proteins in the setting of heart failure. This group of proteins regulates the mitochondrial membrane potential and therefore plays a role in mitochondrial energy metabolism as well as reactive oxygen species generation by the mitochondria. This review discusses the role of uncoupling proteins in regulating oxidant stress and implications with respect to the pathogenesis of heart failure and potential treatments.
Authors:
Karl R Laskowski; Raymond R Russell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  5     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2008-12-10     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Disease Progression
Down-Regulation
Energy Metabolism / physiology
Female
Gene Expression Regulation
Heart Failure / metabolism,  physiopathology*
Humans
Ion Channels / genetics,  metabolism*
Male
Mitochondria / metabolism
Mitochondrial Proteins / genetics,  metabolism*
Oxidative Stress / physiology*
RNA, Messenger / analysis
Rats
Reactive Oxygen Species / metabolism*
Sensitivity and Specificity
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
HL077310/HL/NHLBI NIH HHS; R01 HL077310-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Mitochondrial Proteins; 0/RNA, Messenger; 0/Reactive Oxygen Species; 0/mitochondrial uncoupling protein 2; 0/mitochondrial uncoupling protein 3
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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