| Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD. | |
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MedLine Citation:
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PMID: 12882456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mechanical efficiency is reduced in patients with chronic obstructive pulmonary disease (COPD). Furthermore, altered fibre-type distribution and metabolic profile has been observed in peripheral skeletal muscle of COPD patients. Since skeletal muscular uncoupling protein-3 (UCP3) has been implicated in the regulation of energy metabolism, the aim of this study was to assess UCP3 in peripheral skeletal muscle of COPD patients and healthy controls. A total of 16 COPD patients and 11 healthy age-matched control subjects were studied. Mechanical efficiency was measured by means of cycle ergometry. Biopsies were taken from the vastus lateralis, and UCP3 and cytochrome c (as a marker for mitochondrial content) levels were assessed by Western blotting. Muscle fibre types and metabolic profile were examined histochemically. UCP3 levels were markedly decreased in COPD compared to controls. In COPD patients, there was a positive correlation between UCP3 content and the forced expiratory volume in one second. UCP3 content was not related to mechanical efficiency, or other muscular data such as fibre types, markers of oxidative/glycolytic energy metabolism or cytochrome c. The authors of this study conclude that uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with chronic obstructive pulmonary disease and is related to disease severity, but not to mechanical efficiency. The low uncoupling protein-3 content is independent of the loss of oxidative capacity observed in these patients. |
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Authors:
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H R Gosker; P Schrauwen; M K C Hesselink; G Schaart; G J van der Vusse; E F M Wouters; A M W J Schols |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 22 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-28 Completed Date: 2003-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 88-93 Citation Subset: IM |
Affiliation:
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Dept of Pulmonology, Maastricht University, Maastricht, the Netherlands. H.Gosker@pul.unimaas.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Blotting, Western Carrier Proteins / metabolism* Case-Control Studies Energy Metabolism Exercise Test Female Humans Immunohistochemistry Ion Channels Male Middle Aged Mitochondrial Proteins Muscle, Skeletal / metabolism* Pulmonary Disease, Chronic Obstructive / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Ion Channels; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein 3 |
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