| Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women. | |
| | |
MedLine Citation:
|
PMID: 21530798 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Uncoupling protein 1 (UCP1) plays an important role in thermogenesis in brown adipose tissue. Previously, we reported an association between -3826 A/G single-nucleotide polymorphism (SNP) in the promoter of UCP1 gene and lower thermogenesis in young women, suggesting this SNP has an adverse effect on the regulation of energy balance. Based on the hypothesis that this SNP (G allele) may have resistance against diet-induced weight loss, we examined its effects on anthropometric and metabolic responses to short-term, controlled-energy diet in young women. Seventeen lean women (20.9 ± 0.2 years; body mass index, 22.1 ± 0.5 kg/m(2)) were fed a controlled-energy diet (5.0 MJ/d, 62% carbohydrate, 19% protein, and 19% fat) administered by dietitians for 2 weeks. Clinical measurements were determined at baseline and after the dietary intervention. The subjects' physical activity was obtained using pedometers and self-reporting. The thermoregulatory sympathetic nervous system was evaluated using heart rate variability power spectral analysis. Upon the completion of the intervention, subjects were genotyped using an allele-specific DNA primer assay and results compared with their clinical measurements focusing on with or without the G allele. After dietary intervention, G allele subjects (A/G + G/G, n = 10) showed significantly smaller changes in body weight, body mass index, and waist circumference compared with A/A genotype subjects (n = 7). Similar changes were observed in parameters regarding glucose or lipid metabolism in both groups. These results suggest that the UCP1 gene -3826 G allele may result in smaller weight loss after a short-term, controlled-energy diet in young, lean women. |
| | |
Authors:
|
Narumi Nagai; Naoki Sakane; Kazuhiko Kotani; Taku Hamada; Kokoro Tsuzaki; Toshio Moritani |
Related Documents
:
|
12173068 - Up-regulation of liver glucose-6-phosphatase in x-linked hypophosphatemic mice. 10626648 - Relative bioavailability of phosphorus in feed and agricultural phosphates for poultry. 2396488 - Phospholipid and ganglioside composition in rat cerebral cortex and cerebral white matt... 3146008 - Liver adenosine triphosphate and ph in fasted and well-fed mice after infusion of adeni... 15333718 - Growth potential, but not body weight or moderate limitation of lysine intake, affects ... 16478958 - Tolerance of inorganic selenium by range-type ewes during gestation and lactation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nutrition research (New York, N.Y.) Volume: 31 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 255-61 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Food Science and Nutrition, School of Human Science and Environment, University of Hyogo, Hyogo 670-0092, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Silver nanoparticles fluorescence enhancement effect for determination of nucleic acids with kaempfe...
Next Document: All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and r...