| Uncoupling of biological oscillators: a complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. | |
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MedLine Citation:
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PMID: 8674321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To present a complementary hypothesis concerning the pathogenesis of the multiple organ dysfunction syndrome. DATA SOURCES: Primary reports and reviews published in peer-reviewed medical and scientific journals. HYPOTHESIS: We suggest that healthy organs behave as biological oscillators, which couple to one another during human development, and that this orderly coupling is maintained through a communications network, including neural, humoral, and cytokine components. We suggest that the systemic inflammatory response syndrome initiates disruption of communication and uncoupling, and further suggest that progression into the multiple organ dysfunction syndrome reflects progressive uncoupling that can become irreversible. Resolution of the inflammatory response and reestablishment of the communications network are necessary but may not be, by itself, sufficient to allow organs to appropriately recouple. This hypothesis is testable using existing laboratory and clinical tools. |
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Authors:
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P J Godin; T G Buchman |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Critical care medicine Volume: 24 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-09 Completed Date: 1996-08-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1107-16 Citation Subset: AIM; IM |
Affiliation:
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National Institutes of Health, Bethesda, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart / physiopathology Humans Inflammation / physiopathology Models, Theoretical Multiple Organ Failure / physiopathology* Respiratory System / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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GM00581/GM/NIGMS NIH HHS |
| Comments/Corrections | |
Comment In:
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Crit Care Med. 1997 Mar;25(3):555
[PMID:
9118677
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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