| Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women With polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20156067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) manifest impaired insulin-stimulated release of a d-chiro-inositol-containing inositolphosphoglycan (DCI-IPG) insulin mediator during oral glucose tolerance testing (OGTT), which appears to be restored by the administration of metformin. This suggests that either obesity or PCOS is associated with a defect in the coupling of the stimulation of the insulin receptor by insulin to the release of the DCI-IPG mediator. The objective of this study was to compare the release of bioactive DCI-IPG between normal nonobese women and obese PCOS women during stimulation with two different concentrations of insulin when glucose levels are clamped. METHODS: We performed a cross-sectional case-control study at the clinical research center of an academic medical center. A two-step euglycemic-hyperinsulinemic clamp was carried out in 8 nonobese normal and 8 obese PCOS women, during which DCI-IPG bioactivity was monitored. RESULTS: At baseline, PCOS women were significantly more obese, hyperinsulinemic, and insulin resistant than the controls. During the clamp studies, DCI-IPG bioactivity increased significantly over the first 45 min of the low-insulin step of the clamp in normal nonobese women (P = 0.046) and then decreased to baseline levels; DCI-IPG increased again after initiation of the high-insulin step (P = 0.029). Despite higher insulin levels during the clamp in PCOS women, DCI-IPG bioactivity remained flat throughout both insulin steps and was thus significantly lower than in controls during the initial periods of both steps. CONCLUSIONS: The coupling between insulin action and the release of the DCI-IPG mediator is selectively impaired in obese PCOS women, which may contribute to the insulin resistance in these women. |
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Authors:
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Jean-Patrice Baillargeon; Maria J Iuorno; Teimuraz Apridonidze; John E Nestler |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolic syndrome and related disorders Volume: 8 ISSN: 1557-8518 ISO Abbreviation: Metab Syndr Relat Disord Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-08-06 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: United States |
Other Details:
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Languages: eng Pagination: 127-36 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke, Quebec, Canada. JP.Baillargeon@USherbrooke.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Cross-Sectional Studies Diazoxide / administration & dosage, pharmacology Female Glucose Clamp Technique Humans Hypoglycemic Agents / administration & dosage, pharmacology Inositol / chemistry, secretion* Inositol Phosphates / chemistry, metabolism, secretion* Insulin / administration & dosage, blood, metabolism*, pharmacology Obesity / blood, complications, metabolism* Polycystic Ovary Syndrome / blood, complications, metabolism* Polysaccharides / chemistry, metabolism, secretion* Signal Transduction / drug effects Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K24HD40237/HD/NICHD NIH HHS; R01 HD035629-13/HD/NICHD NIH HHS; R01HD35629/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Inositol Phosphates; 0/Polysaccharides; 0/inositol phosphate glycan; 11061-68-0/Insulin; 364-98-7/Diazoxide; 6917-35-7/Inositol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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