| Uncoupling and Antioxidant Effects of Ursolic Acid in Isolated Rat Heart Mitochondria. | |
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MedLine Citation:
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PMID: 21648406 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ursolic acid (1), a pentacyclic triterpene acid, is one of the major components of certain traditional medicinal plants and possesses a wide range of biological effects, such as anti-inflammatory, antioxidative, and cytotoxic activities. Furthermore, 1, when present at 1.6-5 ng/mL concentrations in commercial herbal preparations used for patients with cardiac disorders, may also exert pro-cardiac activities. There are several indirect suggestions that the cardioprotective mechanism of ursolic acid could involve the mitochondria; however the mechanism of action is still not known. Therefore, the effects of 0.4-200 ng/mL ursolic acid (1) on the functions of isolated rat heart mitochondria oxidizing either pyruvate and malate, succinate, or palmitoyl-l-carnitine plus malate were investigated. It was found that 1 induced a statistically significant uncoupling of oxidative phosphorylation. A statistically significant decrease in H(2)O(2) production in the mitochondria was observed after incubation with 5 ng/mL 1. This effect was comparable to the effectiveness of the classical uncoupler carbonyl cyanide 3-chlorophenylhydrazone. Since mild mitochondrial uncoupling has been proposed as one of the mechanisms of cardioprotection, the present results indicate that ursolic acid (1) has potential use as a cardioprotective compound. |
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Authors:
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Julius Liobikas; Daiva Majiene; Sonata Trumbeckaite; Lolita Kursvietiene; Ruta Masteikova; Dalia M Kopustinskiene; Arunas Savickas; Jurga Bernatoniene |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-7 |
Journal Detail:
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Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute for Biomedical Research, Academy of Medicine, Lithuanian University of Health Sciences , Eiveniu 4, LT-50009, Kaunas, Lithuania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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