Document Detail

Uncoupler of oxidative phosphorylation prolongs the lifespan of Drosophila.
MedLine Citation:
PMID:  16266268     Owner:  NLM     Status:  MEDLINE    
The effect of a moderate ("soft") uncoupling of mitochondria on the lifespan and some parameters of biological age of Drosophila melanogaster strain Oregon was studied. Addition of the uncoupler 2,4-dinitrophenol (DNP) to the nutritional mixture of larvae significantly increased the average lifespan of the flies without changing their maximal lifespan. DNP significantly increased the rate of oxygen consumption by isolated mitochondria and tissue homogenates of the flies in state 4 (of Chance). DNP also decreased the activity of alcohol dehydrogenase (a parameter of flies' biological age) in the tissue homogenates, especially on octanol as the reaction substrate. However, being deprived of food the DNP-treated flies displayed a markedly decreased viability as compared to the control flies. On the whole, the results suggest that "soft" uncoupling of mitochondria may increase the lifespan.
V I Padalko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry. Biokhimii͡a     Volume:  70     ISSN:  0006-2979     ISO Abbreviation:  Biochemistry Mosc.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-11-03     Completed Date:  2006-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376536     Medline TA:  Biochemistry (Mosc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  986-9     Citation Subset:  IM    
Institute of Biology, Karazin Kharkov National University, 61077 Kharkov, Ukraine.
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MeSH Terms
2,4-Dinitrophenol / pharmacology*
Alcohol Dehydrogenase / drug effects,  metabolism
Drosophila melanogaster / drug effects,  enzymology,  metabolism*
Longevity / drug effects*
Mitochondria / drug effects,  metabolism
Oxidative Phosphorylation / drug effects*
Oxygen Consumption / drug effects,  physiology
Uncoupling Agents / metabolism,  pharmacology*
Reg. No./Substance:
0/Uncoupling Agents; 51-28-5/2,4-Dinitrophenol; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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