| Unconventional vessel wall apposition in off-pump porcine coronary artery bypass grafting: low versus high graft flow. | |
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MedLine Citation:
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PMID: 11828295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Facilitated coronary anastomosis techniques may involve unconventional vessel wall apposition in contrast to standard intima-intima apposition. We assessed the patency, anastomotic thrombus formation, and intimal hyperplasia of unconventional intima-adventitia apposition versus conventional suturing techniques in beating heart coronary bypass grafting under low versus high graft flow conditions. METHODS: The intima-adventitia (n = 28) and conventional anastomoses (n = 28) were evaluated intraoperatively (n = 56), at 4 hours (n = 20), and at 5 weeks (n = 36) in a new off-pump low-flow (n = 28) and high-flow (n = 28) porcine bypass model (< or = 15 mL/min and about 60 mL/min, respectively). The anastomoses were assigned to the animals by means of randomized stratification and examined by means of flow measurements, angiography, and histology. RESULTS: Mean graft flows in intima-adventitia and in conventional anastomoses were similar (P =.709). All but 1 of 56 anastomoses (low flow conventional) were fully patent at the time of death. At 4 hours, only small platelet depositions were found at the exposed media and adventitia in the unconventional anastomoses. At 5 weeks, little streamlining intimal hyperplasia was found, which was comparable between the anastomoses (P =.600). CONCLUSIONS: In low-flow conditions (< or = 15 mL/min) unconventional intima-adventitia apposition was not detrimental to the internal thoracic-coronary artery anastomosis in the pig. This finding may expand design strategies of facilitated coronary artery bypass anastomosis techniques. |
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Authors:
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Marc P Buijsrogge; Paul F Gründeman; Cees W J Verlaan; Cornelius Borst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 123 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-05 Completed Date: 2002-03-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 341-7 Citation Subset: AIM; IM |
Affiliation:
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Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Animals Blood Flow Velocity Coronary Artery Bypass* Female Follow-Up Studies Internal Mammary-Coronary Artery Anastomosis* Suture Techniques Swine Time Factors Vascular Patency |
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