| Uncontrolled viral replication as a risk factor for non-AIDS severe clinical events in HIV-infected patients on long-term antiretroviral therapy: APROCO/COPILOTE (ANRS CO8) cohort study. | |
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MedLine Citation:
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PMID: 19474755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine risk factor for non-AIDS severe clinical events in HIV-infected patients on long-term combination antiretroviral therapy (cART). METHODS: A validation committee reviewed each severe clinical event that occurred in the APROCO/COPILOTE (ANRS CO8) cohort that enrolled 1281 patients in 1997-1999 at the initiation of cART containing protease inhibitor. Probability of the occurrence of a first non-AIDS, cART-related, and AIDS-defining event was estimated, and potential determinants were studied using Cox regression models. RESULTS: During a median follow-up of 7.3 years, the incidence of non-AIDS events was higher than that of cART-related and AIDS-defining events (10.5, 3.6, and 2.6 per 100 patient-years, respectively). Bacterial (mainly airway) infections were the most frequent non-AIDS events (23.4%) followed by non-AIDS-defining malignancies and cardiovascular events (both 9.5%). Factors independently associated with the occurrence of a first non-AIDS event were age >60 years [hazard ratio (HR) 2.1; 95% confidence interval (CI): 1.3 to 3.2] and CD4 <100 cells per milliliter (HR 2.5; 95% CI: 1.8 to 3.6) but also plasma HIV RNA >4 log10 copies per milliliter at the time of the event (HR 1.9; 95% CI: 1.5 to 2.5). CONCLUSION: Optimization and permanent continuation of long-term antiretroviral therapy in HIV-infected patients is the best strategy to prevent or reduce the occurrence of non-AIDS severe morbidity. |
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Authors:
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Tristan Ferry; François Raffi; Fidéline Collin-Filleul; Michel Dupon; Pierre Dellamonica; Anne Waldner; Christophe Strady; Geneviève Chêne; Catherine Leport; Vincent Le Moing; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 51 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 407-15 Citation Subset: IM; X |
Affiliation:
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Service de Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Université Claude Bernard Lyon 1, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult CD4 Lymphocyte Count Cohort Studies Drug Therapy, Combination Female HIV Infections / complications*, drug therapy, virology Humans Male Prospective Studies Risk Factors Viral Load Virus Replication* |
| Investigator | |
Investigator/Affiliation:
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C Leport / ; F Raffi / ; G Chêne / ; R Salamon / ; J-P Moatti / ; J Pierret / ; B Spire / ; F Brun-Vézinet / ; H Fleury / ; B Masquelier / ; G Peytavin / ; R Garraffo / ; D Costagliola / ; P Dellamonica / ; C Katlama / ; L Meyer / ; D Salmon / ; A Sobel / ; L Cuzin / ; M Dupon / ; X Duval / ; V Le Moing / ; B Marchou / ; T May / ; P Morlat / ; C Rabaud / ; A Waldner-Combernoux / ; F Collin-Filleul / ; Nadine Job-Spira / ; Marcia Trumeau / ; C Perronne / ; V Le Moing / ; C Lewden / ; J Biemar / ; S Boucherit / ; A D Bouhnik / ; C Brunet-François / ; M P Carrieri / ; F Couturier / ; J L Ecobichon / ; V Guiyedi / ; P Kurkdji / ; S Martiren / ; M Préau / ; C Protopopescu / ; C Roy / ; J Surzyn / ; A Taieb / ; V Villes / ; C Wallet / ; J L Schmit / ; J M Chennebault / ; J P Faller / ; J L Dupond / ; J M Estavoyer / ; Drobachef / ; O Bouchaud / ; M Dupon / ; Longy-Boursier / ; P Morlat / ; J M Ragnaud / ; P Granier / ; M Garré / ; R Verdon / ; D Merrien / ; A Devidas / ; A Sobel / ; H Portier / ; C Perronne / ; P Lagarde / ; J Ceccaldi / ; D Peyramond / ; C Allard / ; J Reynes / ; T May / ; F Raffi / ; J G Fuzibet / ; P Dellamonica / ; P Arsac / ; E Bouvet / ; F Bricaire / ; P Bergmann / ; J Cabane / ; J Monsonego / ; P M Girard / ; L Guillevin / ; S Herson / ; C Leport / ; M C Meyohas / ; J M Molina / ; G Pialoux / ; D Salmon / ; B Becq-Giraudon / ; R Jaussaud / ; C Michelet / ; F Lucht / ; T Debord / ; J M Lang / ; J P De Jaureguiberry / ; B Marchou / ; J M Besnier / |
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