| Uncontrolled plasma proteolysis: a major threat to the septicemic patient. | |
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MedLine Citation:
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PMID: 3024278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to further elucidate the pathophysiological significance of plasma proteolysis during septicemia, surgical patients with septicemia were studied by means of chromogenic peptide substrate assays. In fatal cases continuous low values for prekallikrein, plasminogen and antithrombin III were found until death. At autopsy a persistent septic focus was found in all but one of the fatal cases. Very low levels of prekallikrein during sepsis and reduced functional inhibition of plasma kallikrein in septic shock indicated a poor prognosis. In the survivors the parameters returned towards the normal range upon successful therapy. Furthermore the paper demonstrates the application of a new parameter, the proenzyme functional inhibition index (PFI-index) in patients with septicemia. The data reveal that by means of this parameter patients at high risk can be identified at an early stage of the disease. |
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Authors:
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A O Aasen; N Smith-Erichsen; E Amundsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Resuscitation Volume: 14 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-06 Completed Date: 1987-01-06 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: IRELAND |
Other Details:
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Languages: eng Pagination: 33-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antithrombin III
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analysis* Humans Kallikreins / analysis* Plasminogen / analysis* Prekallikrein / analysis* Prognosis Risk Sepsis / blood*, enzymology |
| Chemical | |
Reg. No./Substance:
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9000-94-6/Antithrombin III; 9001-91-6/Plasminogen; 9055-02-1/Prekallikrein; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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