| Unconjugated hyperbilirubinemia in nonalcoholic steatohepatitis--is it Gilbert's syndrome? | |
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MedLine Citation:
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PMID: 16512459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with nonalcoholic steatohepatitis (NASH) have normal liver function tests except for raised transaminases until they have progressed to cirrhosis of liver. The objective of this study was to evaluate patients of NASH for the presence of hyperbilirubinemia at presentation. METHOD: Sixty-seven patients of NASH were studied for the presence of hyperbilirubinemia at presentation. All patients were worked up for the presence of cirrhosis and hemolytic work up and fasting test were done in those found with unconjugated hyperbilirubinemia. RESULTS: Five out of 67 patients (7.5%) of NASH were found to have unconjugated hyperbilirubinemia. Though the fasting test was not positive, they all had a negative hemolytic workup and none of them had underlying cirrhosis. Clinical characteristics of patients with unconjugated hyperbilirubinemia were similar to those with normal serum bilirubin levels. CONCLUSION: Unconjugated hyperbilirubinemia in patients with NASH may suggest an associated Gilbert's syndrome. |
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Authors:
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Ajay Duseja; Ashim Das; Reena Das; R K Dhiman; Yogesh Chawla; A Bhansali |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Tropical gastroenterology : official journal of the Digestive Diseases Foundation Volume: 26 ISSN: 0250-636X ISO Abbreviation: Trop Gastroenterol Publication Date: 2005 Jul-Sep |
Date Detail:
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Created Date: 2006-03-03 Completed Date: 2006-04-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8107122 Medline TA: Trop Gastroenterol Country: India |
Other Details:
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Languages: eng Pagination: 123-5 Citation Subset: IM |
Affiliation:
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Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fatty Liver / complications* Female Gilbert Disease / diagnosis Hepatitis / complications* Humans Hyperbilirubinemia / diagnosis, etiology* Male Middle Aged |
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