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Uncomplicated pregnancy and delivery after previous severe postpartum cerebral angiopathy.
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PMID:  22114582     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Postpartum cerebral angiopathy (PCA) is a cerebral vasoconstriction syndrome developing shortly after delivery, without signs of preceding eclampsia. The risk for recurrence of PCA is unknown. Here, we report on a closely monitored, uneventful pregnancy of a woman with a previous severe episode of PCA. In summary, this case report demonstrates that PCA does not necessarily recur in following pregnancies, even after previous severe episodes.
Authors:
Jan Rémi; Thomas Pfefferkorn; Gunther Fesl; Nina Rogenhofer; Andreas Straube; Matthias Klein
Publication Detail:
Type:  Journal Article     Date:  2011-10-11
Journal Detail:
Title:  Case reports in neurology     Volume:  3     ISSN:  1662-680X     ISO Abbreviation:  Case Rep Neurol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-11-24     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
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Nlm Unique ID:  101517693     Medline TA:  Case Rep Neurol     Country:  Switzerland    
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Languages:  eng     Pagination:  252-7     Citation Subset:  -    
Affiliation:
Departments of Neurology, University of Munich, Munich, Germany.
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Journal ID (nlm-ta): Case Rep Neurol
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ISSN: 1662-680X
Publisher: S. Karger AG, Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch
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Copyright © 2011 by S. Karger AG, Basel
open-access:
collection publication date: Season: Sep-Dec Year: 2011
Electronic publication date: Day: 11 Month: 10 Year: 2011
pmc-release publication date: Day: 11 Month: 10 Year: 2011
Volume: 3 Issue: 3
First Page: 252 Last Page: 257
ID: 3220894
PubMed Id: 22114582
DOI: 10.1159/000333782
Publisher Id: crn0003-0252

Uncomplicated Pregnancy and Delivery after Previous Severe Postpartum Cerebral Angiopathy
Jan Rémia
Thomas Pfefferkorna
Gunther Feslb
Nina Rogenhoferc
Andreas Straubea
Matthias Kleina*
aDepartments of Neurology, University of Munich, Munich, Germany
bDepartments of Neuroradiology, University of Munich, Munich, Germany
cDepartments of Gynaecology, Klinikum Grosshadern, University of Munich, Munich, Germany
Correspondence: **Matthias Klein, MD, Department of Neurology, University of Munich, Marchioninistrasse 15, DE–81377 Munich (Germany), Tel. +49 89 7095 3144, E-Mail matthias.klein@med.uni-muenchen.de

Introduction

Postpartum cerebral angiopathy (PCA) is a cerebral vasoconstriction syndrome developing shortly after delivery, without signs of preceding eclampsia. The risk for recurrence of PCA is unknown. Here, we report on a closely monitored, uneventful pregnancy of a woman with a previous severe episode of PCA [1].


Case Report

A 32-year-old female patient was first treated at our university hospital when she developed a severe episode of PCA after delivery of her second child [1]. Briefly, she suffered from cerebral vasoconstriction and subsequent ischemic lesions (fig. 1), becoming symptomatic, with an acute onset of very severe headache 4 days after delivery, left-sided hemianopia, and generalized tonic-clonic seizures. Signs of eclampsia were not present. Intra-arterial and subsequent intravenous nimodipine led to lasting improvement. Follow-up MRA showed a clear resolution of vasoconstriction 7 and 15 days after diagnosis. The patient was discharged without deficits, but was advised to have her status re-evaluated before a next pregnancy.

Eight months after this first episode, the patient presented to our outpatient clinic being 6 weeks pregnant. She had no neurological complaints. An MRI showed only the previously documented lesions. Over the course of her pregnancy, no signs of vasoconstriction or epileptic activity were identified on repeated neurological examinations, EEGs, or MRIs and transcranial Doppler ultrasounds (TCD).

After 40 weeks of pregnancy, our patient had an uncomplicated vaginal delivery of a healthy boy. As during the second pregnancy, she had not received any medications having PCA as a possible side effect [2]. No neurological signs or symptoms occurred after delivery. Daily TCD from 3 days before to 10 days after delivery did not reveal signs of vasoconstriction. No new lesions (fig. 2) or signs of vasoconstriction were seen on MRI. At follow-up 6 months later, the patient was well without complaints.


Discussion

PCA is considered a rare, possibly underdiagnosed [2], but serious neurological complication in delivering women [3, 4]. It is one of several reversible cerebral vasoconstriction syndromes (RCVS), characterized by reversible vasoconstriction of the cerebral arteries. RCVS are usually associated with an acute onset of thunderclap headache with or without neurologic deficits [4]. The pathophysiology of RCVS is thought to involve an acute change in cerebrovascular tone [2], which may be spontaneous or evoked by various exogenous or endogenous factors, with an uncertain pathophysiological mechanism [5, 6, 7]. It is not clear whether vasospasm, vasculitis or another mechanism or factor is the underlying reason for PCA [6, 8], but the pathophysiology may be similar to the disease mechanisms in eclampsia [9]. Since it is known that the risk of a repeated pre-eclampsia is more than twice as high as the risk in the general population, it is justified to consider that there is also an increased risk for repeated PCA in patients with PCA in a previous pregnancy [10].

For eclampsia, the rate of recurrence may be as high as 50% [11], but for RCVS in general, and PCA in particular, these data are not available, especially since patients are typically advised to avoid the triggering factors [2]. In a literature review, we only found one report on the recurrence of PCA where a patient had severe intracranial hemorrhages after two consecutive pregnancies [12]. In comparison, our patient's course of her third pregnancy is encouraging, as it demonstrates no recurrence of PCA even after a previous severe episode of PCA.

Although conventional angiography is, by definition, the gold standard, non-invasive investigations such as MRI and CT of the brain and cerebral vessels have been largely used to support the diagnosis and follow-up. The results of the brain MRI are frequently normal in RCVS but can reveal evidence of infarction as well as parenchymal hemorrhages and small non-aneurysmal subarachnoid hemorrhages on the cortical surface. Furthermore, with the development of the MRI technique, the quality of the MRA rapidly becomes better.

PCA may recur; however, we do not know the rate of recurrence. Therefore, patients with pregnancies following an episode of PCA should be monitored closely. Due to the very limited number of cases and the lack of studies, it is unclear what surveillance of the patients would make sense. Of course, the basis for close monitoring are neurologic examinations on the days before and after delivery. Besides clinical monitoring, TCD seems an ideal tool to monitor patients for the development of cerebral vasoconstriction. TCD is non-invasive, has no side effects, is easy to perform, and is cheap. We chose to monitor our patient closely by TCD, checking for an increase of cerebral blood flow velocities monthly during the last 4 months of pregnancy and daily from 3 days before to 10 days after delivery. Furthermore, we recommend an MRA and MRI whenever clinical signs consistent with PCA develop (e.g. headaches, seizures, focal neurologic deficits). Since our patient had suffered from an epileptic seizure during PCA, we also performed an EEG the week before and after delivery to rule out epileptiform discharges.

For the treatment of severe episodes of PCA, calcium channel blockers are used, but only with little substantiating evidence [1, 13]. Occurrence of subclinical signs of vasoconstriction on MRA or TCD may warrant consideration of oral nimodipine even before the onset of clinical signs.

Due to the lack of evidence, counseling patients with PCA with respect to following pregnancies is difficult compared to other gestational diseases [11], but our report is encouraging compared to a previous report on recurrence of PCA with most severe complications [12]. However, further studies are certainly needed to adequately understand the risk of a new pregnancy and to understand factors contributing to PCA. Until more comprehensive data on new pregnancies is available, close monitoring is recommended.


Disclosure Statement

No author has any conflict of interest to disclose.


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Article Categories:
  • Published: October, 2011

Keywords: Key words Postpartum cerebral angiopathy, Reversible cerebral vasoconstriction syndrome, Vasospasm, Stroke, Pregnancy.

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