Document Detail


Uncommon vancomycin-induced side effects.
MedLine Citation:
PMID:  12204187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the red man syndrome . Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA bullous dermatosis, necrotizing cutaneous vasculitis and toxic epidermal necrolysis. Only two cases of vancomycin-induced Stevens-Johnson syndrome and one case of pancytopenia have been reported in the medical literature. The treatment for both situations is based on cessation of the vancomycin therapy; in cases of Stevens-Johnson syndrome, antihistamine and/or steroid agents can be used. This article reports a case of pancytopenia and a case of erythema major associated with neutropenia.
Authors:
Jaime Luis Lopes Rocha; William Kondo; Maria Inêz Domingues Kuchiki Baptista; Clovis Arns Da Cunha; Luzmila Terezinha Flenik Martins
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  6     ISSN:  1413-8670     ISO Abbreviation:  Braz J Infect Dis     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2003-01-15     Revised Date:  2007-04-24    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  196-200     Citation Subset:  IM    
Affiliation:
Division of Infectious Disease, Nossa Senhora das Graças Hospital, Curitiba, Paraná, Brazil. jaimeluis@b.com.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Anti-Infective Agents / therapeutic use
Eosinophilia / chemically induced
Erythema / chemically induced*
Female
Fever / chemically induced
Hip Prosthesis
Humans
Methicillin Resistance
Middle Aged
Neutropenia / chemically induced*
Ofloxacin / therapeutic use
Prosthesis-Related Infections / drug therapy
Pruritus / chemically induced
Staphylococcus / isolation & purification
Syndrome
Vancomycin / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 1404-90-6/Vancomycin; 82419-36-1/Ofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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