Document Detail


Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.
MedLine Citation:
PMID:  15774759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Cells in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.
Authors:
Shuzhen Hao; James W Sharp; Catherine M Ross-Inta; Brent J McDaniel; Tracy G Anthony; Ronald C Wek; Douglas R Cavener; Barbara C McGrath; John B Rudell; Thomas J Koehnle; Dorothy W Gietzen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  307     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-18     Completed Date:  2005-03-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1776-8     Citation Subset:  IM    
Affiliation:
School of Veterinary Medicine, Department of Anatomy, Physiology and Cell Biology, University of California, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Acylation
Amino Acids, Essential / administration & dosage*,  analysis,  deficiency*
Animals
Diet
Eating
Eukaryotic Initiation Factor-2 / metabolism*
Food*
Food Preferences
Leucine / administration & dosage,  analogs & derivatives*,  pharmacology
Mice
Mice, Inbred C57BL
Olfactory Pathways / metabolism*
Phosphorylation
Protein Kinases / metabolism*
Protein-Serine-Threonine Kinases
RNA, Transfer / metabolism*
Rats
Stereoisomerism
Threonine / administration & dosage
eIF-2 Kinase / metabolism
Grant Support
ID/Acronym/Agency:
GM49164/GM/NIGMS NIH HHS; NS043231/NS/NINDS NIH HHS; NS33347/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids, Essential; 0/Eukaryotic Initiation Factor-2; 61-90-5/Leucine; 72-19-5/Threonine; 7533-40-6/leucinol; 9014-25-9/RNA, Transfer; EC 2.7.-/Protein Kinases; EC 2.7.10.-/PERK kinase; EC 2.7.11.1/Eif2ak4 protein, mouse; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/eIF-2 Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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