| Unchanged noradrenaline reactivity and blood pressure after corrective surgery in primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 8210970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate the role of the hyperparathyroid state for blood pressure and volume homeostasis, eight patients with primary hyperparathyroidism were studied before and after corrective surgery. Neither noradrenaline induced blood pressure changes nor basal blood pressure were affected by the operation, and the values were the same as in an age- and sex-matched control group. Noradrenaline infusion induced an increase in PTH(1-84) values before (72-86 ng l-1, medians, p < 0.02), in contrast to a decrease after (28 to 19 ng l-1, p < 0.05) operation for primary hyperparathyroidism. Basal plasma atrial natriuretic peptide was lower before than after removal of adenomata (3.2 vs. 4.8 pmol l-1, medians, p < 0.02). Cyclic 3'-5'-guanosine monophosphate was not significantly changed (4.7 vs. 5.5 nmol l-1). Aldosterone was higher before than after surgery (139 vs. 71 pmol l-1, p < 0.02), whereas angiotensin II was unaltered (20 vs. 9 pmol l-1). Arginine vasopressin was higher before than after the operation (0.9 vs. 0.7 pmol l-1, p < 0.05), but urinary excretion of prostaglandin E2 was unchanged. In conclusion primary hyperparathyroidism was not associated with changes in noradrenaline reactivity or basal blood pressure despite derangements of hormones adjusting sodium and water homeostasis. It is suggested that the hormonal changes may be secondary to a relative volume depletion. |
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Authors:
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B Jespersen; A Brock; P Charles; H Danielsen; S S Sørensen; E B Pedersen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 53 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-11-05 Completed Date: 1993-11-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 479-86 Citation Subset: IM |
Affiliation:
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Department of Medicine and Nephrology C, Skejby Hospital, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin II / blood Atrial Natriuretic Factor / blood Blood Pressure / drug effects* Calcium / blood Cyclic GMP / blood Dinoprostone / urine Female Humans Hyperparathyroidism / physiopathology*, surgery Male Middle Aged Norepinephrine / pharmacology* Sodium / urine |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 363-24-6/Dinoprostone; 51-41-2/Norepinephrine; 7440-23-5/Sodium; 7440-70-2/Calcium; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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