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Unchanged heat-shock protein 70 expression in myocardium of patients with permanent atrial fibrillation.
MedLine Citation:
PMID:  21124290     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: Cardiomyocytes respond to permanent atrial fibrillation (AF) with an increase in mitochondrial heat shock proteins (Hsp). The aim of our study was to test if there is a cytoplasmic response to stress by investigating the expression of Hsp70.
METHODS: Right atrial samples from 18 patients undergoing elective cardiac surgery were excised and immediately frozen in liquid nitrogen. Eight patients had permanent AF (>3 months) and 10 patients were in sinus rhythm (SR). Hsp70 was determined by SDS-PAGE, Western blot and quantified with optical densitometry.
RESULTS: We found no increase in Hsp70 expression in myocardial samples from patients with permanent AF.
CONCLUSION: The unchanged expression of Hsp70 may indicate that the cytoplasmic stress response in permanent AF is exhausted.
Authors:
A E Schäfler; A Hannekum; K Kirmanoglou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  51     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  923-7     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, University of Ulm,, Ulm, Germany - aschaefler@gmx.de.
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