| Unchanged heat-shock protein 70 expression in myocardium of patients with permanent atrial fibrillation. | |
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MedLine Citation:
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PMID: 21124290 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: Cardiomyocytes respond to permanent atrial fibrillation (AF) with an increase in mitochondrial heat shock proteins (Hsp). The aim of our study was to test if there is a cytoplasmic response to stress by investigating the expression of Hsp70. METHODS: Right atrial samples from 18 patients undergoing elective cardiac surgery were excised and immediately frozen in liquid nitrogen. Eight patients had permanent AF (>3 months) and 10 patients were in sinus rhythm (SR). Hsp70 was determined by SDS-PAGE, Western blot and quantified with optical densitometry. RESULTS: We found no increase in Hsp70 expression in myocardial samples from patients with permanent AF. CONCLUSION: The unchanged expression of Hsp70 may indicate that the cytoplasmic stress response in permanent AF is exhausted. |
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Authors:
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A E Schäfler; A Hannekum; K Kirmanoglou |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of cardiovascular surgery Volume: 51 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: Italy |
Other Details:
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Languages: eng Pagination: 923-7 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, University of Ulm,, Ulm, Germany - aschaefler@gmx.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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