Document Detail


Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury.
MedLine Citation:
PMID:  19752272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cephalothin (cefalotin) pharmacokinetics were evaluated for nine severely burned patients (42% +/- 9% mean burn areas) and five healthy volunteers by using non-plasma-protein-bound concentration-time profiles. Burn patients gave increased mean residence times (36%) and reduced total clearances (25%). Mean residence times and distribution volumes increased between 1 and 4 days posttrauma, suggesting that burn patient pharmacokinetics change during the initial fluid resuscitation phase of treatment.
Authors:
Andrew J Dalley; Renae Deans; Jeffrey Lipman; Bala Venkatesh; Michael Rudd; Michael S Roberts; Sheree E Cross
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-14
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  53     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-02-01     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5303-5     Citation Subset:  IM    
Affiliation:
University of Queensland, Burns Trauma & Critical Care Research Centre, Royal Brisbane & Women's Hospital, Herston, Brisbane, Queensland, Australia. a.dalley@uq.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Bacterial Agents / pharmacokinetics*,  therapeutic use*
Burns / drug therapy*
Cephalothin / pharmacokinetics*,  therapeutic use*
Female
Humans
Male
Middle Aged
Time Factors
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 153-61-7/Cephalothin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes...
Next Document:  Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode...