| Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury. | |
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MedLine Citation:
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PMID: 19752272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cephalothin (cefalotin) pharmacokinetics were evaluated for nine severely burned patients (42% +/- 9% mean burn areas) and five healthy volunteers by using non-plasma-protein-bound concentration-time profiles. Burn patients gave increased mean residence times (36%) and reduced total clearances (25%). Mean residence times and distribution volumes increased between 1 and 4 days posttrauma, suggesting that burn patient pharmacokinetics change during the initial fluid resuscitation phase of treatment. |
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Authors:
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Andrew J Dalley; Renae Deans; Jeffrey Lipman; Bala Venkatesh; Michael Rudd; Michael S Roberts; Sheree E Cross |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-14 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 53 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2010-02-01 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 5303-5 Citation Subset: IM |
Affiliation:
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University of Queensland, Burns Trauma & Critical Care Research Centre, Royal Brisbane & Women's Hospital, Herston, Brisbane, Queensland, Australia. a.dalley@uq.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / pharmacokinetics*, therapeutic use* Burns / drug therapy* Cephalothin / pharmacokinetics*, therapeutic use* Female Humans Male Middle Aged Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 153-61-7/Cephalothin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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