| Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. | |
| | |
MedLine Citation:
|
PMID: 22260693 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The anti-inflammatory effects of the prototypical second messenger cAMP have been extensively documented in multiple cell types. One mechanism by which these effects are achieved is via Epac1 (exchange protein directly activated by cAMP 1)-dependent induction of SOCS-3 (suppressor of cytokine signalling 3), which binds and inhibits specific class I cytokine receptors. One important aspect of SOCS-3 functionality is its role as the specificity determinant within an E3 ubiquitin ligase complex which targets cellular substrates for polyubiquitylation and proteasomal degradation. In the present review, we describe key inhibitory processes that serve to reduce cytokine receptor signalling, focusing primarily on SOCS protein function and regulation. We also outline a strategy we have developed to identify novel ubiquitylated substrates for the Epac1-inducible SOCS-3 E3 ubiquitin ligase complex following purification of the ubiquitinome. It is anticipated that identifying substrates for the Epac1-regulated SOCS-3 E3 ubiquitin ligase, and assessment of their functional significance, may pinpoint new sites for therapeutic intervention that would achieve therapeutic efficacy of cAMP-elevating drugs while minimizing the adverse effects usually associated with these agents. |
| | |
Authors:
|
Jamie J L Williams; Timothy M Palmer |
Related Documents
:
|
19922463 - Bortezomib restores stroma-mediated apo2l/trail apoptosis resistance in multiple myeloma. 22563853 - Cranberry proanthocyanidins act in synergy with licochalcone a to reduce porphyromonas ... 19734463 - Epithelial gm-csf induction by candida glabrata. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biochemical Society transactions Volume: 40 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
|
Languages: eng Pagination: 215-8 Citation Subset: IM |
Affiliation:
|
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects.
Next Document: cAMP-dependent allostery and dynamics in Epac: an NMR view.