Document Detail

Unbalanced protein S deficiency due to warfarin treatment as a possible cause for thrombosis.
MedLine Citation:
PMID:  17897308     Owner:  NLM     Status:  MEDLINE    
The prothrombin time/International Normalized Ratio is an accurate parameter for following most warfarin-treated patients. However, it reflects mostly factor VII levels, and significant disproportionate alterations in other vitamin K-dependent factors may not be reflected properly. We report a rare case of a woman who developed arterial thrombosis whilst receiving therapeutic doses of warfarin, and was found to have a significant and unbalanced protein S deficiency. Discontinuation of warfarin resulted in complete normalization of coagulation factors, and no further thrombotic events under treatment with enoxaparin, with a follow-up of 2.5 years.
Michal Z Haran; Inna Lichman; Alain Berebbi; Eran Weinmann; Nurit Rosenberg
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  139     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-27     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-1     Citation Subset:  IM    
Haematology Institute, Kaplan Medical Centre, Rehovot, Israel.
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MeSH Terms
Anticoagulants / adverse effects*,  therapeutic use
Enoxaparin / therapeutic use
Follow-Up Studies
International Normalized Ratio
Middle Aged
Protein S Deficiency / blood*
Thrombosis / blood,  etiology*,  prevention & control
Warfarin / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Anticoagulants; 0/Enoxaparin; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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