| Unbalanced protein S deficiency due to warfarin treatment as a possible cause for thrombosis. | |
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MedLine Citation:
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PMID: 17897308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prothrombin time/International Normalized Ratio is an accurate parameter for following most warfarin-treated patients. However, it reflects mostly factor VII levels, and significant disproportionate alterations in other vitamin K-dependent factors may not be reflected properly. We report a rare case of a woman who developed arterial thrombosis whilst receiving therapeutic doses of warfarin, and was found to have a significant and unbalanced protein S deficiency. Discontinuation of warfarin resulted in complete normalization of coagulation factors, and no further thrombotic events under treatment with enoxaparin, with a follow-up of 2.5 years. |
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Authors:
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Michal Z Haran; Inna Lichman; Alain Berebbi; Eran Weinmann; Nurit Rosenberg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 139 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-27 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 310-1 Citation Subset: IM |
Affiliation:
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Haematology Institute, Kaplan Medical Centre, Rehovot, Israel. michal.haran@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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adverse effects*,
therapeutic use Enoxaparin / therapeutic use Female Follow-Up Studies Humans International Normalized Ratio Middle Aged Protein S Deficiency / blood* Thrombosis / blood, etiology*, prevention & control Warfarin / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Enoxaparin; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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