Document Detail

Unbalanced 6p translocation as primary karyotypic anomaly in secondary acute nonlymphocytic leukemia.
MedLine Citation:
PMID:  1591714     Owner:  NLM     Status:  MEDLINE    
A case of acute nonlymphocytic leukemia after radiochemotherapy for Hodgkin's disease, with a rearrangement of 6p23 region, is described. This chromosome change, which has been previously reported in secondary leukemias or myelodysplastic syndromes, was an isolated karyotypic anomaly in our case, which strongly supports the nonrandom involvement of chromosome 6p in induced leukemias.
M Mancini; C Mecucci; M Cedrone; M B Rondinelli; M A Aloe-Spiriti; G Alimena
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  60     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-02     Completed Date:  1992-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-5     Citation Subset:  IM    
Hematology, Department of Human Biopathology, University of Rome La Sapienza, Italy.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Chromosomes, Human, Pair 6*
Hodgkin Disease / drug therapy*,  radiotherapy*
Leukemia, Myeloid, Acute / chemically induced,  etiology,  genetics*
Leukemia, Radiation-Induced / genetics
Translocation, Genetic*

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