Document Detail


Unanchoring integrins in focal adhesions.
MedLine Citation:
PMID:  23033047     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.
Authors:
Johanna Ivaska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  981-3     Citation Subset:  IM    
Affiliation:
Turku Centre for Biotechnology, University of Turku, and VTT Technical Research Centre of Finland, Turku 20520, Finland.
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