Document Detail

Unaltered strong immunohistochemical expression of CD44-v6 and -v5 isoforms during development and progression of oral squamous cell carcinomas.
MedLine Citation:
PMID:  8959559     Owner:  NLM     Status:  MEDLINE    
The present study was designed to immunolocalize CD44-v6 and -v5 isoforms in normal, dysplastic and malignant oral mucosa as well as in primary and metastatic oral squamous cell carcinomas. Routinely formalin-fixed and paraffin-embedded tissues of 100 oral carcinoma patients were immunohistochemically investigated following wet autoclave antigen retrieval. Both CD44-v6 and -v5 epitopes were uniformly strongly expressed on the cell surface of basal and intermedial epithelial cells of normal and dysplastic mucosa and in all primary and metastatic squamous cell carcinomas with the exception of end-differentiated keratinizing cells. Our results strongly suggest that CD44-v6 and -v5 isoform expression is not altered during development and progression of oral carcinomas. Thus, they seem to be irrelevant factors in the prediction of prognosis in this type of cancer.
J Piffkò; A Bànkfalvi; K Klauke; R Dreier; U Joos; W Böcker; K W Schmid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  25     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  502-6     Citation Subset:  D; IM    
Department of Cranio-Maxillofacial Surgery, University of Münster, Germany.
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MeSH Terms
Antigens, CD44 / classification,  genetics*
Antigens, Neoplasm / classification,  genetics*
Antigens, Surface / classification,  genetics
Carcinoma, Squamous Cell / immunology,  pathology*,  secondary
Cell Differentiation / genetics
Disease Progression
Epithelium / immunology,  pathology
Epitopes / classification,  genetics
Gene Expression Regulation, Neoplastic
Keratinocytes / immunology,  pathology
Middle Aged
Mouth Mucosa / immunology,  pathology
Mouth Neoplasms / immunology,  pathology*
Paraffin Embedding
Tissue Fixation
Reg. No./Substance:
0/Antigens, CD44; 0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Epitopes; 0/Fixatives; 50-00-0/Formaldehyde

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