| Unaltered strong immunohistochemical expression of CD44-v6 and -v5 isoforms during development and progression of oral squamous cell carcinomas. | |
MedLine Citation:
|
PMID: 8959559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was designed to immunolocalize CD44-v6 and -v5 isoforms in normal, dysplastic and malignant oral mucosa as well as in primary and metastatic oral squamous cell carcinomas. Routinely formalin-fixed and paraffin-embedded tissues of 100 oral carcinoma patients were immunohistochemically investigated following wet autoclave antigen retrieval. Both CD44-v6 and -v5 epitopes were uniformly strongly expressed on the cell surface of basal and intermedial epithelial cells of normal and dysplastic mucosa and in all primary and metastatic squamous cell carcinomas with the exception of end-differentiated keratinizing cells. Our results strongly suggest that CD44-v6 and -v5 isoform expression is not altered during development and progression of oral carcinomas. Thus, they seem to be irrelevant factors in the prediction of prognosis in this type of cancer. |
Authors:
|
J Piffkò; A Bànkfalvi; K Klauke; R Dreier; U Joos; W Böcker; K W Schmid |
Related Documents
:
|
1384369 - Basaloid squamous cell carcinoma of the head and neck. a clinicopathologic and immunohi... 8625559 - Cultured kaposi's sarcoma tumor cells fail to stimulate t cell proliferation. 1951669 - Enhancement of kallikrein production and kinin sensitivity in t84 cells by growth in th... 18507059 - Gypenosides inhibited invasion and migration of human tongue cancer scc4 cells through ... 9439969 - Comparison of immunostainings for proliferating cell nuclear antigen and ki-67 in human... 15720799 - Increased expression of the ezh2 polycomb group gene in bmi-1-positive neoplastic cells... 576239 - Invasion of lymphosarcoma cells into the perfused mouse liver. 23057509 - Organ growth without cell division: somatic polyploidy in a moth, ephestia kuehniella. 21465469 - Cementum protein 1 (cemp1) induces a cementoblastic phenotype and reduces osteoblastic ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 25 ISSN: 0904-2512 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1997-03-20 Completed Date: 1997-03-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 502-6 Citation Subset: D; IM |
Affiliation:
|
Department of Cranio-Maxillofacial Surgery, University of Münster, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigens, CD44
/
classification,
genetics* Antigens, Neoplasm / classification, genetics* Antigens, Surface / classification, genetics Carcinoma, Squamous Cell / immunology, pathology*, secondary Cell Differentiation / genetics Disease Progression Epithelium / immunology, pathology Epitopes / classification, genetics Female Fixatives Forecasting Formaldehyde Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Keratinocytes / immunology, pathology Male Middle Aged Mouth Mucosa / immunology, pathology Mouth Neoplasms / immunology, pathology* Paraffin Embedding Prognosis Tissue Fixation |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD44; 0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Epitopes; 0/Fixatives; 50-00-0/Formaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of sodium lauryl sulphate on the expression of cytokeratin mRNA in hamster cheek pouch ep...
Next Document: Reduced expression of dipeptidyl peptidase (DPP) IV in peripheral blood T lymphocytes of oral cancer...