| Unaltered innervation of the human cervix uteri in contrast to the corpus during pregnancy and labor as revealed by PGP 9.5 immunohistochemistry. | |
| | |
MedLine Citation:
|
PMID: 16188372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the occurrence of the general neuronal marker protein gene product 9.5 (PGP 9.5) in the human corpus (isthmus region) and the cervix uteri during pregnancy and parturition STUDY DESIGN: Biopsies were taken from the upper edge of the hysterotomy during caesarean section (CS) at term (n=5), in labor (n=5) and from the corresponding area in the non-pregnant uterus after hysterectomy (n=5). Cervical biopsies were obtained transvaginally from the anterior cervical lip. Serial cryostate sections were prepared for immunohistochemistry using polyclonal antibodies to PGP 9.5. RESULTS: Nerve fibers displaying PGP 9.5 immunoreactivity were observed in all sections from the three groups examined. They were identified in muscle tissue, in the stroma, and around blood vessel walls. A 30-fold decline of immunoreactive nerve fibers was observed in the isthmus part of the corpus uteri at term compared to the non-pregnant. There were no significant differences between the immunoreactivity in the cervix uteri of the three groups CONCLUSIONS: The innervation of the cervix uteri is dense and unaltered throughout pregnancy and labor. In contrast, the corpus is almost denervated. Further studies are needed to clarify the reason and the impact of these findings. |
| | |
Authors:
|
Berith K Tingåker; Olle Johansson; Ann Hjelm Cluff; Gunvor Ekman-Ordeberg |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-26 |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 125 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-28 Completed Date: 2006-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 66-71 Citation Subset: IM |
Affiliation:
|
Karolinska Institute, Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Hospital, SE-171 76 Stockholm, Sweden. Berith.Tingaker@kbh.ki.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biopsy Cervix Uteri / blood supply, innervation* Cesarean Section Female Humans Hysterectomy Hysterotomy Immunohistochemistry Labor Pain / physiopathology Labor, Obstetric / physiology Pregnancy Ubiquitin Thiolesterase / analysis* Uterus / blood supply, innervation* |
| Chemical | |
Reg. No./Substance:
|
EC 3.1.2.15/UCHL1 protein, human; EC 3.1.2.15/Ubiquitin Thiolesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Laparoscopic treatment of endometriosis in teenagers.
Next Document: Intraamniotic ethacridine lactate instillation versus vaginal PGE1 in second trimester termination o...