Document Detail


Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels.
MedLine Citation:
PMID:  20604643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aetiology of polycystic ovary syndrome (PCOS) is poorly understood, but an intrauterine hyperandrogenic environment has been implicated. This study was designed to assess whether the female offspring of mothers with PCOS are exposed to raised levels of testosterone (T) in utero. In this case-control study, three groups of pregnant women were recruited from the labour ward: PCOS women with a female baby (n = 10, PCOS girls); control women with a female baby (n = 20, control girls) and control women with a male baby (n = 10, control boys). Maternal and umbilical vein (UV) blood was assayed for T levels. UV T in PCOS girls was significantly raised, compared with control girls (p < 0.012). The difference in UV T between PCOS girls and control boys was not significant (p < 0.254). This is the first demonstration of a hyperandrogenic in utero environment in PCOS pregnancies; UV T in female infants is raised to male levels.
Authors:
J A Barry; A R Kay; R Navaratnarajah; S Iqbal; J E A K Bamfo; A L David; M Hines; P J Hardiman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  30     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  444-6     Citation Subset:  IM    
Affiliation:
Department of Psychology, City University, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Androgens / blood
Case-Control Studies
Female
Fetal Blood
Humans
Hyperandrogenism / blood*,  complications*
Male
Polycystic Ovary Syndrome / blood*,  etiology*
Pregnancy
Prenatal Exposure Delayed Effects*
Testosterone / blood*
Umbilical Veins
Chemical
Reg. No./Substance:
0/Androgens; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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