| Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-alpha) in preterm and term neonates. | |
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MedLine Citation:
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PMID: 17168979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The objective of this study was to explore the relationship between labor (preterm and term) and umbilical blood serum regulated on activation, normal T cell expressed and secreted (RANTES) and melanoma growth stimulatory activity/growth-related oncogene-a (MSGA/GRO-alpha) concentration, and to determine whether early sepsis and pneumonia are associated with changes in concentrations of the chemokines (RANTES and MSGA/GRO-alpha) in umbilical blood serum. METHODS: Umbilical blood was obtained from 67 neonates in the following groups: (i) preterm neonates with early sepsis; (ii) preterm neonates with pneumonia; (iii) non-infected preterm neonates; and (iv) full-term healthy neonates. RANTES and MGSA/GRO-alpha concentrations were determined by use of a commercially available immunoassay kit. RESULTS: Non-infected preterm neonates had lower RANTES concentrations than healthy term neonates. Preterm infected neonates (pneumonia or sepsis) did not have higher RANTES concentrations than non-infected preterm neonates. In contrast, non-infected preterm neonates had higher MSGA/GRO-alpha concentrations than full-term healthy neonates. And preterm neonates with sepsis had higher MGSA/GRO-alpha concentrations than preterm ones with pneumonia and non-infected preterm ones. CONCLUSIONS: Preterm neonates had constitutively lower RANTES concentrations than term ones and it seems that during infection RANTES concentrations did not increase. MGSA/GRO-a concentrations were constitutively higher in preterm than term neonates, and septic events further increased its concentrations in preterm neonates. |
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Authors:
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Barbara Królak-Olejnik; Brygida Beck; Igor Olejnik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 48 ISSN: 1328-8067 ISO Abbreviation: Pediatr Int Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-15 Completed Date: 2007-01-24 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
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Languages: eng Pagination: 586-90 Citation Subset: IM |
Affiliation:
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Department of Perinatology, Medical University of Silesia, Chorzow, Poland. olejnik@pik-net.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteremia
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blood Case-Control Studies Chemokine CCL5 / blood* Chemokine CXCL1 Chemokines, CXC / blood* Fetal Blood / chemistry* Humans Infant, Newborn Infant, Premature / blood* Perinatology Pneumonia / blood* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/CXCL1 protein, human; 0/Chemokine CCL5; 0/Chemokine CXCL1; 0/Chemokines, CXC |
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