Document Detail

Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-alpha) in preterm and term neonates.
MedLine Citation:
PMID:  17168979     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of this study was to explore the relationship between labor (preterm and term) and umbilical blood serum regulated on activation, normal T cell expressed and secreted (RANTES) and melanoma growth stimulatory activity/growth-related oncogene-a (MSGA/GRO-alpha) concentration, and to determine whether early sepsis and pneumonia are associated with changes in concentrations of the chemokines (RANTES and MSGA/GRO-alpha) in umbilical blood serum. METHODS: Umbilical blood was obtained from 67 neonates in the following groups: (i) preterm neonates with early sepsis; (ii) preterm neonates with pneumonia; (iii) non-infected preterm neonates; and (iv) full-term healthy neonates. RANTES and MGSA/GRO-alpha concentrations were determined by use of a commercially available immunoassay kit. RESULTS: Non-infected preterm neonates had lower RANTES concentrations than healthy term neonates. Preterm infected neonates (pneumonia or sepsis) did not have higher RANTES concentrations than non-infected preterm neonates. In contrast, non-infected preterm neonates had higher MSGA/GRO-alpha concentrations than full-term healthy neonates. And preterm neonates with sepsis had higher MGSA/GRO-alpha concentrations than preterm ones with pneumonia and non-infected preterm ones. CONCLUSIONS: Preterm neonates had constitutively lower RANTES concentrations than term ones and it seems that during infection RANTES concentrations did not increase. MGSA/GRO-a concentrations were constitutively higher in preterm than term neonates, and septic events further increased its concentrations in preterm neonates.
Barbara Królak-Olejnik; Brygida Beck; Igor Olejnik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  48     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-01-24     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  586-90     Citation Subset:  IM    
Department of Perinatology, Medical University of Silesia, Chorzow, Poland.
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MeSH Terms
Bacteremia / blood
Case-Control Studies
Chemokine CCL5 / blood*
Chemokine CXCL1
Chemokines, CXC / blood*
Fetal Blood / chemistry*
Infant, Newborn
Infant, Premature / blood*
Pneumonia / blood*
Retrospective Studies
Reg. No./Substance:
0/CXCL1 protein, human; 0/Chemokine CCL5; 0/Chemokine CXCL1; 0/Chemokines, CXC

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