Document Detail

Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term.
MedLine Citation:
PMID:  15592286     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to determine the relationship of umbilical cord pH and base excess (BE) values to adverse neonatal outcomes for a large tertiary hospital population delivering at term. Study design The perinatal/neonatal database of St. Joseph's Health Care, London, Canada, was used to obtain the umbilical cord pH and BE values, incidence of adverse neonatal outcomes, and patient demographics for all term (>/=37 weeks' gestation), singleton, liveborn infants with no major anomalies delivering between November 1995 and March 2002 (n=20,456). Statistical analyses included chi(2) analysis, logistic regression models to develop odds ratios and creation of receiver operating characteristic (ROC) curves with area under curve (AUC) calculations. RESULTS: Umbilical vein and artery pH and BE values for this tertiary care population averaged 7.33 +/- 0.06 and 7.24 +/- 0.07, and -4.5 +/- 2.4 and -5.6 +/- 3.0 mmol/L, respectively. Apgar less than 7 at 5 minutes, neonatal intensive care unit (NICU) admission, and assisted neonatal ventilation had significant inverse relationships with both umbilical artery and umbilical vein pH and BE (all P < .0001), with marginal increases in the incidences of these outcomes beginning with cord blood values close to the mean, and more substantial increases with cord values less than 1 or 2 SD below the mean, depending on the outcome studied. The ROC AUC for all these relationships were significant (P < .001) ranging from 0.76 to 0.79 when predicting Apgar less than 7 at 5 minutes to 0.68 to 0.70 when predicting NICU admission, and with cutoff cord blood values at which sensitivity and specificity were maximized again close to mean values. For each of these neonatal outcomes, the relation to cord blood values was similar with little difference in the data analysis whether using pH or BE values, and whether from the umbilical artery or vein. CONCLUSION: There is a progression of risk in term infants for Apgar less than 7 at 5 minutes, NICU admission, and need for assisted ventilation with worsening acidosis at birth, which begins with cord blood values close to mean values indicating a higher threshold for associated acidemia with these outcomes than is seen for more severe neonatal outcomes.
Rahi Victory; Deborah Penava; Orlando Da Silva; Renato Natale; Bryan Richardson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-01-27     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2021-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Paediatrics and Physiology, St. Joseph's Health Care, University of Western Ontario, London, Ontario, Canada.
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MeSH Terms
Acid-Base Imbalance / diagnosis*,  epidemiology
Apgar Score
Asphyxia Neonatorum / diagnosis*,  epidemiology
Blood Gas Analysis
Fetal Blood / chemistry*
Follow-Up Studies
Hydrogen-Ion Concentration*
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  epidemiology
Intensive Care Units, Neonatal
Logistic Models
Pregnancy Trimester, Third
ROC Curve
Retrospective Studies
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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