Document Detail

Umbilical cord and neonatal cortisol levels. Effect of gestational and neonatal factors.
MedLine Citation:
PMID:  733134     Owner:  NLM     Status:  MEDLINE    
To evaluate the effect of the type of delivery, gestational age, maternal dexamethasone treatment, and neonatal complications on the serum cortisol levels in early infancy, a total of 92 neonates were investigated with 611 cortisol determinations (specific radioimmunoassay after Lipidex chromatography). Umbilical cord blood samples were taken immediately after delivery and capillary blood samples from the infant's heel 30--60 minutes after delivery and at 8:00 AM and PM on the second, fourth, and sixth days of life. Umbilical cord cortisol concentration after elective cesarean section was lower than after emergency cesarean section or after normal vaginal delivery, while neonatal cortisol values did not show any correlation with the type of delivery. Prematurity did not affect neonatal cortisol levels. In postterm infants the activation of cortisol production was retarded to some degree. After maternal dexamethasone therapy, neonatal cortisol concentration decreased 30--60 minutes after delivery, but from the second day on it was at the same level as in infants without maternal therapy. Respiratory distress syndrome, especially in fatal cases, caused an elevation in neonatal cortisol levels, while hyperbilirubinemia did not have an effect on plasma cortisol concentrations of the neonates.
A Kauppila; M Koivisto; M Pukka; R Tuimala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  52     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-72     Citation Subset:  AIM; IM    
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MeSH Terms
Cesarean Section
Delivery, Obstetric / methods
Dexamethasone / pharmacology,  therapeutic use
Fetal Blood
Gestational Age
Hydrocortisone / blood*
Infant, Newborn*
Jaundice, Neonatal / complications
Respiratory Distress Syndrome, Newborn / complications,  prevention & control
Reg. No./Substance:
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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