| Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia. | |
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MedLine Citation:
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PMID: 12662167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A correlation between elevation of pro-inflammatory cytokines and white matter injury or abnormal neurologic outcome has been established in the preterm infant. In the full-term neonate, few studies exist linking elevation of cytokines with encephalopathy and poor neurodevelopmental outcome. Our aims were to investigate if serum interleukin-6 concentrations in delivering mothers and their offspring at birth are associated with perinatal asphyxia, and to examine the relation of interleukin-6 levels to the severity of hypoxic-ischemic encephalopathy and to the neurological outcome. DESIGN AND METHODS: Serum interleukin-6 levels were measured at birth, 24 and 48 h of life in 50 consecutive term uninfected newborns with perinatal asphyxia and 113 randomly selected healthy term newborns, and at delivery in their mothers. RESULTS: The median cord interleukin-6 concentrations in the infants who developed hypoxic-ischemic encephalopathy was 376-fold as high as the values in the normal infants (P < 0.0001) and 5.5-fold as high as those in the infants with asphyxia who did not develop hypoxic-ischemic encephalopathy (P < 0.05). There was also a significant relationship between interleukin-6 and the degree of hypoxic-ischemic encephalopathy, and between interleukin-6 and neurodevelopmental outcome at 2 years of age. Regardless of outcome, in the asphyxiated infants the interleukin-6 values were significantly lower at both 24 and 48 h of life than at birth, with a significant decline from 24 to 48 h of life. Among mothers of the asphyxiated neonates, there were no significant differences in interleukin-6 concentrations between those delivering neonates with and without hypoxic-ischemic encephalopathy. CONCLUSIONS: Measurement of IL-6 concentrations in the umbilical cord of neonates with perinatal asphyxia may be useful to identify early, and in a relatively simple way, those who are most likely to have subsequent brain injury and adverse outcome. |
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Authors:
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C Chiesa; G Pellegrini; A Panero; T De Luca; M Assumma; F Signore; L Pacifico |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 33 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-28 Completed Date: 2003-07-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: England |
Other Details:
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Languages: eng Pagination: 352-8 Citation Subset: IM |
Affiliation:
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National Research Council, Rome, Italy. Claudio.Chiesa@Uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asphyxia Neonatorum / blood*, complications Female Humans Hypoxia-Ischemia, Brain / etiology, metabolism Infant, Newborn Interleukin-6 / blood* Male Prospective Studies Umbilical Cord / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
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