Document Detail

Umbilical cord ghrelin in term and preterm newborns and its relation to metabolic hormones and anthropometric measurements.
MedLine Citation:
PMID:  20334115     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to assess umbilical cord ghrelin level in term and preterm newborns and its relation to other metabolic hormones and anthropometric measurements. A cross sectional comparative study included 50 normal appropriate-for-gestational-age newborns (25 full-terms; 25 preterm). Assessment of anthropometric measurements, cord levels of ghrelin, leptin, insulin and glucose were done to all newborns. Umbilical cord ghrelin was detected in all newborns. There was no significant difference between term and preterm groups regarding ghrelin, insulin and glucose. Leptin was significantly lower in preterm than term group. Sex and mode of delivery had no effects regarding all studied variables. There was no overall correlation between ghrelin and gestational age, anthropometric measurements, leptin, insulin or glucose in all newborns. Preterm group demonstrated significant correlations between ghrelin and weight, body mass index and abdominal circumference. An overall significant correlation was found between leptin and gestational age and anthropometric measurements in all newborns. In preterm group leptin correlated with weight, length, subscapular skin-fold thickness and abdominal circumference. To conclude the umbilical cord ghrelin was relatively invariable at birth between 30 and 41 weeks gestation showing no gestational age-related variation, unlike leptin, which was lower in preterm group indicating increased adipose mass and placental maturation with increased gestational age.
Safaa S Imam; Manal E Kandil; M Shoman; Salwa I Baker; R Bahier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  12     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  1548-55     Citation Subset:  IM    
Department of Pediatrics, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Cross-Sectional Studies
Gestational Age
Ghrelin / analysis*
Infant, Newborn*
Infant, Premature*
Leptin / analysis
Umbilical Cord / chemistry*
Reg. No./Substance:
0/Ghrelin; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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