Document Detail


Umbilical cord blood transplantation and cytomegalovirus: Posttransplantation infection and donor screening.
MedLine Citation:
PMID:  16926290     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed the incidence of cytomegalovirus (CMV) infection after transplantation of cord blood (CB) from unrelated donors and evaluated strategies for screening CB donors. Posttransplantation CMV infection, reported in 23% of 1221 CB recipients, was associated with patient pretransplantation CMV serology (P < .001), but not with CMV serology in CB donors or their mothers. A total of 26 988 infant CB donors were evaluated by viral culture of saliva. Subgroups were evaluated by polymerase chain reaction in CB (CB-PCR) in 2 case-control studies. In the first study, 33 of 47 saliva culture-positive CB donors were confirmed by CB-PCR. All mothers of the 33 infants with confirmed CMV infection were CMV-total antibody positive, but only 1 of 3 had CMV-IgM antibody. The second study evaluated infants born to mothers with CMV-IgM antibody. Of these, 5 of 170 saliva culture-negative infants were positive by CB-PCR. The incidence of congenital CMV infection in CB donors was low (0.12%). Maternal serology had poor predictive value for CMV infection in their infant CB donors and bore no detected relationship to CMV infection in CB recipients. Saliva culture for CMV had both false-positive and -negative results. CB-PCR was a useful alternative for detecting CMV in CB donors.
Authors:
Maria S Albano; Patricia Taylor; Robert F Pass; Andromachi Scaradavou; Rodica Ciubotariu; Carmelita Carrier; Ludy Dobrila; Pablo Rubinstein; Cladd E Stevens
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study     Date:  2006-08-22
Journal Detail:
Title:  Blood     Volume:  108     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-06     Completed Date:  2007-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4275-82     Citation Subset:  AIM; IM    
Affiliation:
National Cord Blood Program, New York Blood Center, 310 E 67 St, New York, NY 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Viral / blood
Child
Child, Preschool
Cord Blood Stem Cell Transplantation* / adverse effects
Cytomegalovirus* / genetics
Cytomegalovirus Infections / blood,  congenital,  etiology,  genetics,  prevention & control*
DNA, Viral / blood*,  genetics
Donor Selection* / methods
False Negative Reactions
False Positive Reactions
Female
Humans
Immunoglobulin M / blood
Infant
Infant, Newborn
Male
Polymerase Chain Reaction / methods
Predictive Value of Tests
Retrospective Studies
Saliva / virology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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