Document Detail

Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants.
MedLine Citation:
PMID:  22494936     Owner:  NLM     Status:  Publisher    
Perfluoroalkyl acids (PFAAs) and polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants representing two classes of environmental contaminants of toxicological concern, especially for infants. Canadian biomonitoring data on these chemicals are limited. The objectives of this study were to measure PFAAs and PBDEs in umbilical cord blood from approximately 100 hospital deliveries in Ottawa (Ontario, Canada) and examine associations with characteristics of the mother and infant. Geometric means were 1.469ng/mL for perfluorooctanoate (PFOA) (95% confidence interval of 1.292-1.671ng/mL), 4.443ng/mL for perfluorooctane sulfonate (PFOS) (95% CI of 3.735-5.285ng/mL), 0.359ng/mL for perfluorononanoic acid (PFNA) (95% CI of 0.318-0.404ng/mL), and 0.579ng/mL for perfluorohexanesulfonate (PFHxS) (95% CI of 0.473-0.709ng/mL). The final multiple regression models indicated that lower gravida, term gestational age, smoking during pregnancy and vaginal delivery were significantly associated with higher levels of PFOS. Similarly, a vaginal delivery was significantly associated with higher PFOA, while weak associations were found with lower gravida and birth weight less than 2500g. Furthermore, higher PFNA concentrations were significantly associated with older mothers, and vaginal delivery, while weakly associated with term gestational age. Elevated PFHxS concentrations were significantly associated with smoking during pregnancy and lower gravida. Similar to reports from other countries, the preponderant PBDE congener measured in the cord blood was PBDE-47. Questions remain on why various studies have reported conflicting results on the association between PFAAs and birth weight.
Tye E Arbuckle; Cariton Kubwabo; Mark Walker; Karelyn Davis; Kaela Lalonde; Ivana Kosarac; Shi Wu Wen; Douglas L Arnold
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-9
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  -     ISSN:  1618-131X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier GmbH. All rights reserved.
Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Canada.
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