| Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus. | |
| | |
MedLine Citation:
|
PMID: 22511615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Maternal anti-Ro autoantibodies are associated with cardiac manifestations of neonatal lupus (cardiac NL), yet only 2% of women with this reactivity have an affected child. Identification of a more specific marker would channel intense monitoring to fetuses at greater risk. This study aimed to determine whether autoantibodies against Ro 52 amino acids 200-239 (p200) confer added risk over autoantibodies to full-length Ro 52, Ro 60, or La. METHODS: Anti-Ro-exposed pregnancies resulting in cardiac NL or no cardiac manifestations were identified from the Research Registry for Neonatal Lupus and the PR Interval and Dexamethasone Evaluation study. Umbilical cord (n = 123) and maternal (n = 115) samples were evaluated by enzyme-linked immunosorbent assay. RESULTS: The frequencies of p200, Ro 52, Ro 60, and La autoantibodies were not significantly different between affected and unaffected children. However, neonatal anti-Ro 52 and Ro 60 titers were highest in cardiac NL and their unaffected siblings compared to unaffected neonates without a cardiac NL sibling. Although both maternal anti-Ro 52 and p200 autoantibodies were less than 50% specific for cardiac NL, anti-p200 was the least likely of the Ro autoantibodies to be false-positive in mothers who have never had an affected child. Titers of anti-Ro 52 and p200 did not differ during a cardiac NL or unaffected pregnancy from the same mother. CONCLUSION: Maternal reactivity to p200 does not confer an added risk to fetal conduction defects over full-length Ro 52 or Ro 60 autoantibodies. Mothers who may never be at risk for having an affected child have lower anti-Ro 60 titers and may require less stringent echocardiographic monitoring compared to women with high-titer autoantibodies. |
| | |
Authors:
|
Joanne H Reed; Robert M Clancy; Kristen H Lee; Amit Saxena; Peter M Izmirly; Jill P Buyon |
Related Documents
:
|
18177665 - Female mating receptivity inhibited by injection of male-derived extracts in callosobru... 15384345 - Influence of cotton fruit stages as food sources on boll weevil (coleoptera: curculioni... 6542235 - Suppression of postpartum fertility in pairs of female rats sharing the same nesting en... 22483705 - Psychotropics in pregnancy: safety and other considerations. 17298725 - Cryoloop vitrification of human day 3 cleavage-stage embryos: post-vitrification develo... 11171725 - Transcatheter embolotherapy of maternal pulmonary arteriovenous malformations during pr... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Arthritis care & research Volume: 64 ISSN: 2151-4658 ISO Abbreviation: Arthritis Care Res (Hoboken) Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-08-28 Completed Date: 2012-11-01 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: United States |
Other Details:
|
Languages: eng Pagination: 1373-81 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 by the American College of Rheumatology. |
Affiliation:
|
New York University School of Medicine, New York, USA. joanne.reed@nyumc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Antinuclear
/
blood* Biological Markers / blood Enzyme-Linked Immunosorbent Assay Female Fetal Blood / immunology* Heart Block / blood, etiology*, immunology Humans Immunodominant Epitopes* Linear Models Lupus Erythematosus, Systemic / blood, congenital*, etiology, immunology Male Peptide Fragments / immunology* Pregnancy Registries Ribonucleoproteins / immunology* Risk Assessment Risk Factors United States |
| Grant Support | |
ID/Acronym/Agency:
|
N01 AR042220/AR/NIAMS NIH HHS; N01-AR-4-2271/AR/NIAMS NIH HHS; R01 AR042455/AR/NIAMS NIH HHS; R01-AR42455-16/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antinuclear; 0/Biological Markers; 0/Immunodominant Epitopes; 0/Peptide Fragments; 0/Ribonucleoproteins; 0/SS-A antibodies; 0/SS-A antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Direct use of the comet assay to study cell cycle distribution and its application to study cell cyc...
Next Document: Highly luminescent CdTe/CdS/ZnO core/shell/shell quantum dots fabricated using an aqueous strategy.