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Umbilical cord blood levels of cortisol and dehydroepiandrosterone sulfate in preterm prelabor rupture of membrane pregnancies complicated by the presence of histological chorioamnionitis.
MedLine Citation:
PMID:  22489862     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: The main aim of this study was to determine the levels of cortisol and dehydroepiandrosterone sulfate (DHEA-S) and the cortisol/DHEA-S ratio in the umbilical cord blood according to the presence of histological chorioamnionitis and fetal inflammatory response in pregnancies complicated by prelabor rupture of membranes at fewer than 34 gestational weeks. Methods: Seventy-two women with singleton pregnancies complicated by preterm prelabor rupture of membranes between gestational ages 24+0 and 33+6 weeks were included in the study. The sample of blood was obtained from the umbilical cord after delivery of the newborn. The umbilical cord blood cortisol and DHEA-S levels were evaluated using commercial immunoassay kits. A cortisol/DHEA-S ratio was calculated. Result: The presence of histological chorioamnionitis was not associated with higher median levels of cortisol (32.1 nmol/L vs. 33.0 nmol/L; p=0.53), DHEA-S (2.6 μmol/L vs. 2.5 μmol/L; p=0.83), or cortisol/DHEA-S ratio (19.5 vs. 18.7; p=0.90). Higher median levels of DHEA-S (3.1 μmol/L vs. 2.3 μmol/L; p=0.03) but not cortisol (91.0 nmol/L vs. 32.0 nmol/L; p=0.06) or cortisol/DHEA-S ratio (24.5 vs. 18.7; p=0.46) were observed when fetal inflammatory responsewas present. Conclusions: The presence of fetal inflammatory responsebut not the presence of histological chorioamnionitis per se was associated with increased DHEA-S levelsin the umbilical cord blood.
Authors:
Marian Kacerovsky; Jaroslava Vavrova; Ivana Musilova; Daniel Lesko; Eva Flidrova; Ctirad Andrys; Helena Hornychova; Erik Dosedla; Bo Jacobsson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Czech Republic.
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