Document Detail


Umbilical artery catheter blood sampling volume and velocity: impact on cerebral blood volume and oxygenation in very-low-birthweight infants.
MedLine Citation:
PMID:  16373299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Blood sampling from umbilical artery catheters decreases cerebral blood volume and cerebral oxygenation. The aim of this study was to assess the impact of sampling volume and velocity. METHODS: Forty-eight infants, median birthweight 965 g (480-1500 g), median gestational age 27 wk (23-34 wk), were studied during routine blood sampling from umbilical artery catheters. The sampling procedure was performed following a strict protocol for draw-up volume (1.6 ml), sampling volume (1.7 ml or 0.2 ml), re-injection volume (1.6 ml) and flushing volume (0.6 ml), time of aspiration (40 s or 80 s), re-injection (30 s) and flushing (6 s). In each infant, sampling volume and aspiration time were subject to sequential variation in a randomized fashion (1.7 ml/40 s, 1.7 ml/80 s, 0.2 ml/30 s). Using near-infrared spectroscopy, changes in concentrations of cerebral oxygenated and deoxygenated haemoglobin were measured, and changes in cerebral blood volume and cerebral oxygenation were calculated. RESULTS: During all three sampling procedures, oxygenated haemoglobin decreased significantly from baseline, whereas deoxygenated haemoglobin did not change. Correspondingly, a decrease in cerebral blood volume and cerebral oxygenation occurred. This decrease was not affected significantly by extending the sampling time from 40 s to 80 s, whereas it was blunted by reducing the amount of blood withdrawn. CONCLUSION: Blood sampling from umbilical artery catheters induces a decrease in cerebral blood volume and cerebral oxygenation. The magnitude of the decrease depends on the blood volume withdrawn but not on sampling velocity.
Authors:
Claudia Roll; Britta Hüning; Matthias Käunicke; Jens Krug; Sandra Horsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  95     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University Hospital, Essen, Germany. Cludia.Roll@kinderklinik-datteln.de
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Blood Specimen Collection / adverse effects,  methods*
Catheterization, Peripheral
Cerebrovascular Circulation*
Female
Heart Rate
Hemoglobins / metabolism
Humans
Infant, Newborn*
Infant, Premature
Infant, Very Low Birth Weight / physiology*
Male
Oximetry
Oxyhemoglobins / metabolism*
Spectroscopy, Near-Infrared
Umbilical Arteries
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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