Document Detail

Umbilical artery Doppler and umbilical cord pH at birth in small-for-gestational-age fetuses: valid estimate of their relationship.
MedLine Citation:
PMID:  15914344     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the relationship between umbilical artery pulsatility index and the umbilical cord pH in small-for-gestational-age fetuses. METHODS: Data were collected from all pregnancies seen in our Fetal Surveillance Unit that underwent antenatal monitoring for being small-for-gestational-age beyond 24 weeks of pregnancy. A linear regression was used to analyse the effect of the umbilical artery pulsatility index (UAPI) and umbilical artery pH at birth, assessing interaction and controlling for clinically meaningful antenatal, Doppler, biophysical and perinatal variables. RESULTS: A total of 117 pregnancies were included. According to the estimated model (which included all clinically significant confounders and statistically significant interactions), in cases with reactive cardiotography (CTG) a 1-unit increase in the UAPI resulted in a mean decrease of 0.021 (95% 0.05 to -0.005) units of umbilical artery pH at delivery. In the non-reactive CTG group a 1-unit increase in the UAPI resulted in a mean decrease of 0.02 (95% CI 0.059 to -0.019) units of umbilical artery pH at delivery. Finally, in fetuses with a pathological CTG a 1-unit increase in the UAPI resulted in a mean decrease of 0.149 (95% CI 0.107 to 0.19) units of umbilical artery pH at delivery. CONCLUSIONS: The crude effect between umbilical artery velocimetry on umbilical artery pH at birth has to be interpreted with caution, since an important part of this effect is related to other factors that confound and modify the relationship. After controlling for confounders, it was only in fetuses with pathological CTG that the effect remained statistically significant.
Francesc Figueras; Elisenda Eixarch; Eva Meler; Montse Palacio; Bienvenido Puerto; Oriol Coll; Josep Figueras; Vicenç Cararach; Antonio J Vanrell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  33     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Department of Obstetrics, Hospital Clinic, Barcelona, Spain.
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MeSH Terms
Delivery, Obstetric / statistics & numerical data
Fetal Blood / chemistry*
Hydrogen-Ion Concentration
Infant, Newborn
Infant, Small for Gestational Age / blood*
Linear Models
Models, Statistical
Pre-Eclampsia / epidemiology
Pregnancy Outcome
Pregnancy, Multiple / statistics & numerical data
Pulsatile Flow / physiology
Risk Factors
Spain / epidemiology
Ultrasonography, Prenatal
Umbilical Arteries / ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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