Document Detail

Ultraviolet-A light in the treatment of rheumatoid arthritis.
MedLine Citation:
PMID:  3440328     Owner:  NLM     Status:  MEDLINE    
Ultraviolet-A (UV-A) light penetrates the epidermis, reaches the macrophages and circulating mononuclear cells within the dermis, and has immunoregulatory effects in humans. We examined the effect of UV-A irradiation on disease activity in 26 patients with rheumatoid arthritis (RA) and on immunologic function in these patients and in 11 normal subjects. Ten joules/cm2/day of total body UV-A irradiation, given 5 days each week for 3 weeks, resulted in significant improvement in the duration of morning stiffness, fatigue, joint tenderness, joint swelling, grip strength, patient assessment of disease activity, and physician assessment of disease activity. Platelet counts decreased significantly in the RA patients. Phytohemagglutinin (PHA)-stimulated lymphocyte production of interleukin-2 (IL-2) increased significantly in the combined RA and normal groups. These results suggest that UV-A light may be effective in the treatment of patients with RA, but elucidation of its precise role will require further study including double-blind trials.
H McGrath; J L Smith; E Bak; J P Michalski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  5     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1987 Oct-Dec
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
Department of Medicine, Louisiana State University School of Medicine, New Orleans 70112.
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MeSH Terms
Arthritis, Rheumatoid / blood,  immunology,  radiotherapy*
Middle Aged
Platelet Count / radiation effects
Skin Tests
Ultraviolet Therapy*

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