Document Detail

Ultraviolet light and cutaneous lupus.
MedLine Citation:
PMID:  17153842     Owner:  NLM     Status:  MEDLINE    
Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining the development of inflammation in lupus patients. We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions.
Marc Bijl; Cees G M Kallenberg
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lupus     Volume:  15     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  724-7     Citation Subset:  IM    
Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
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MeSH Terms
Apoptosis / radiation effects
Autoantibodies / radiation effects
Keratinocytes / radiation effects
Lupus Erythematosus, Cutaneous / etiology*,  immunology,  pathology,  physiopathology
Lupus Erythematosus, Systemic / complications
Radiation Injuries / etiology*,  immunology,  pathology,  physiopathology
Skin / pathology,  radiation effects*
Ultraviolet Rays / adverse effects*
Reg. No./Substance:

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