Document Detail

Ultraviolet-A irradiation but not ultraviolet-B or infrared-A irradiation leads to a disturbed zinc homeostasis in cells.
MedLine Citation:
PMID:  18454944     Owner:  NLM     Status:  MEDLINE    
Changes of the redox balance in cells alter the availability of intracellular free Zn(2+). Here, cells were exposed to ultraviolet (UV)-A, UV-B, or infrared (IR)-A light irradiation, and the intracellular free zinc pool was monitored. Under sublethal conditions only UV-A irradiation resulted in a transient cytoplasmic and nuclear increase of intracellular free Zn(2+). Likewise, tert-butyl hydroperoxide and singlet oxygen, but not H(2)O(2) or intracellular generation of O(2)(*-) by redox cyclers, mimicked the effects of UV-A irradiation, while disulfide stress by diamide only led to a transient cytoplasmic zinc release. These results show that only certain types of subtoxic cellular stress massively disturb the zinc homeostasis in cells.
Elvis Pirev; Christian Calles; Peter Schroeder; Helmut Sies; Klaus-D Kröncke
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Publication Detail:
Type:  Journal Article     Date:  2008-04-30
Journal Detail:
Title:  Free radical biology & medicine     Volume:  45     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-06     Completed Date:  2008-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  IM    
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf, Germany.
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MeSH Terms
Cell Line
Diamide / pharmacology
Fibroblasts / metabolism,  radiation effects
Homeostasis / drug effects,  radiation effects*
Hydrogen Peroxide / pharmacology
Quinones / metabolism
Singlet Oxygen / metabolism
Ultraviolet Rays*
Zinc / metabolism*
Reg. No./Substance:
0/Quinones; 10465-78-8/Diamide; 17778-80-2/Singlet Oxygen; 7440-66-6/Zinc; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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