Document Detail


Ultraviolet-irradiated human endothelial cells elaborate nitric oxide that may evoke vasodilatory response.
MedLine Citation:
PMID:  1282989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human skin absorbs solar ultraviolet radiation which evokes vasodilation by a mechanism that is unknown. In this work, we show that ultraviolet (290-320 nm) irradiation of cultured human endothelial cells with doses (60 mJ/cm2) evoked nitric oxide (NO) release that was sustained for more than 60 min. In addition to augmenting NO, cyclic GMP production by human endothelial cells was also increased in a time-dependent manner. Ultraviolet stimulation of NO production was also observed with the enzyme NO synthase purified from the cytosol of human endothelial cells. These results indicate that ultraviolet radiation stimulates NO release, which stimulates cyclic GMP production by vascular smooth muscle, which results in a relaxation response.
Authors:
G Deliconstantinos; V Villiotou; C Fassitsas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992  
Date Detail:
Created Date:  1993-02-12     Completed Date:  1993-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S63-5     Citation Subset:  IM    
Affiliation:
Department of Experimental Physiology, University of Athens Medical School, Greece.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Oxidoreductases / isolation & purification,  metabolism
Cells, Cultured
Cyclic GMP / metabolism
Endothelium, Vascular / cytology,  metabolism*,  radiation effects
Humans
Muscle, Smooth, Vascular / physiology
Nitric Oxide / metabolism*
Nitric Oxide Synthase
Ultraviolet Rays*
Vasodilation / physiology*
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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