Document Detail

Ultraviolet-irradiated human endothelial cells elaborate nitric oxide that may evoke vasodilatory response.
MedLine Citation:
PMID:  1282989     Owner:  NLM     Status:  MEDLINE    
Human skin absorbs solar ultraviolet radiation which evokes vasodilation by a mechanism that is unknown. In this work, we show that ultraviolet (290-320 nm) irradiation of cultured human endothelial cells with doses (60 mJ/cm2) evoked nitric oxide (NO) release that was sustained for more than 60 min. In addition to augmenting NO, cyclic GMP production by human endothelial cells was also increased in a time-dependent manner. Ultraviolet stimulation of NO production was also observed with the enzyme NO synthase purified from the cytosol of human endothelial cells. These results indicate that ultraviolet radiation stimulates NO release, which stimulates cyclic GMP production by vascular smooth muscle, which results in a relaxation response.
G Deliconstantinos; V Villiotou; C Fassitsas
Related Documents :
12736139 - Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of pero...
23650589 - Effects of carbon monoxide (co) delivery by a co donor or hemoglobin on vascular hypoxi...
10931809 - Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release:...
9140139 - Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial c...
20600009 - Simulated microgravity promotes nitric oxide-supported angiogenesis via the inos-cgmp-p...
19398669 - Mthfr 677 c>t polymorphism reveals functional importance for 5-methyltetrahydrofolate, ...
2123379 - High density lipoproteins and prevention of experimental atherosclerosis with special r...
9718019 - Polymers that reduce intraperitoneal adhesion formation.
24292859 - Anti-inflammatory effects of rutin on hmgb1-induced inflammatory responses in vitro and...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992  
Date Detail:
Created Date:  1993-02-12     Completed Date:  1993-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S63-5     Citation Subset:  IM    
Department of Experimental Physiology, University of Athens Medical School, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Oxidoreductases / isolation & purification,  metabolism
Cells, Cultured
Cyclic GMP / metabolism
Endothelium, Vascular / cytology,  metabolism*,  radiation effects
Muscle, Smooth, Vascular / physiology
Nitric Oxide / metabolism*
Nitric Oxide Synthase
Ultraviolet Rays*
Vasodilation / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7665-99-8/Cyclic GMP; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis.
Next Document:  New method of investigating functional roles of pressure-sensitive mechanoreceptor in human endothel...