Document Detail

Ultraviolet-A1 irradiation decreases clinical disease activity and autoantibodies in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  8039279     Owner:  NLM     Status:  MEDLINE    
In this study we assess the effect of ultraviolet radiation, exclusively within the UV-A1 (340-400 nm) range, on disease activity in SLE. Ten SLE patients were irradiated for 15 days, four of them then continuing treatment for 8 months, with low doses (60 kJ/m2/d) of UV-A1 irradiation. They were assessed clinically and serologically before, after 3 weeks, and after 8 months of therapy. Clinical indices of disease decreased in the 10 patients after 3 weeks by 39%; they decreased in the four patients irradiated for 8 months by 70%. Antibodies to Sjögren's syndrome A (anti-SSA) or antinuclear antibodies (ANA) decreased or disappeared in most patients. There were no side effects. In this uncontrolled study, UV-A1 irradiation appears to have been an effective and seemingly innocuous therapeutic modality for patients with SLE, decreasing signs and symptoms of disease, diminishing levels of autoantibodies and increasing in effectiveness with time.
H McGrath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  12     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1994 Mar-Apr
Date Detail:
Created Date:  1994-08-22     Completed Date:  1994-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM    
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
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MeSH Terms
Antibodies, Antinuclear / analysis
Autoantibodies / analysis*,  radiation effects
Lupus Erythematosus, Systemic / immunology,  physiopathology*,  radiotherapy*
Middle Aged
Sjogren's Syndrome / immunology
Ultraviolet Rays*
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantibodies

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