| Ultrathin-film oscillator biosensors excited by ultrafast light pulses. | |
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MedLine Citation:
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PMID: 20656469 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Novel thin-film oscillator biosensors are developed using picosecond ultrasound method. 100-nm silicon-nitride thin films and 16-nm Pt thin films are used, and ultrashort light pulses are focused on their surfaces to excite the through-thickness resonance vibrations, which are detected by the delayed probe-light pulses using the optoelastic effect. Their fundamental resonance frequencies are 45 and 132 GHz, corresponding to theoretical mass sensitivities of 5.0×10(-5) and 2.2×10(-5) pg/cm(2)/Hz, respectively. These thin-film biosensors are used for detecting human immunoglobulin G (hIgG) with staphylococcus aureus protein A nonspecifically immobilized on the film surfaces. Injection of a 5 nM analyte caused 2% decrease in the resonance frequency. |
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Authors:
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Hirotsugu Ogi; Tetsuya Kawamoto; Nobutomo Nakamura; Masahiko Hirao; Masayoshi Nishiyama |
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Publication Detail:
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Type: Journal Article Date: 2010-07-08 |
Journal Detail:
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Title: Biosensors & bioelectronics Volume: 26 ISSN: 1873-4235 ISO Abbreviation: Biosens Bioelectron Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001289 Medline TA: Biosens Bioelectron Country: England |
Other Details:
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Languages: eng Pagination: 1273-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Graduate School of Engine Science, Osaka University Machikaneyama 1-3, Toyonaka, Osaka 560-8531, Japan. ogi@me.es.osaka-u.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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