Document Detail

Ultrastructure of tumour invasion and desmoplastic response of bronchogenic squamous cell carcinoma.
MedLine Citation:
PMID:  3113068     Owner:  NLM     Status:  MEDLINE    
Using ultrastructural methods we studied the interaction of tumour cells and lung parenchyma in deep areas (i.e., more than about 3 mm from the tumour surface) of 50 bronchogenic squamous cell carcinomas. The tumour periphery, studied previously, had shown organized associations of tumour cells and lung epithelial cells and a surprising lack of invasion of non-epithelial tissue compartments. The deeper areas, where the tumour cells and the lung parenchyma had been in contact for longer periods, consisted of irregular groups of tumour cells and desmoplastic stroma which was very similar to granulation tissue. The deeper areas also contained many intact lung epithelial cells, arranged in compressed and distorted alveolar structures. Where non-neoplastic epithelial cells and tumour cells had direct contact, they formed common junctional complexes and basal laminae. In part of the tumours, the cells were largely devoid of a basal lamina. However, in most instances a continuous basal lamina surrounded every tumour cell group studied, even when these formed irregular strands or seemed to be completely isolated.
K P Dingemans; W J Mooi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  411     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-10     Completed Date:  1987-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  283-91     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Bronchogenic / pathology*,  ultrastructure
Carcinoma, Squamous Cell / pathology*,  ultrastructure
Desmosomes / pathology
Lung Neoplasms / pathology*,  ultrastructure
Neoplasm Invasiveness

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