Document Detail

Ultrastructure of the small intestine in astrovirus-infected lambs.
MedLine Citation:
PMID:  6775050     Owner:  NLM     Status:  MEDLINE    
The ultrastructure of the small intestine of gnotobiotic lambs infected with lamb astrovirus was studied. The virus was observed from 14 to 28 h p.i. in mature columnar epithelial cells covering the apical two-thirds of villi. Crystalline arrays of virus particles with a centre to centre distance of approx. 29 nm were seen in the cytoplasm and virus particles were also observed in apical pits and tubules and in lysosomes. Macrophages containing virus particles in lysosome-like organelles were seen in the lamina propria. Virus particles were released by desquamated cells disintegrating in the gut lumen. Cuboidal cells lining villi appeared from 38 to 70 h p.i., and by 120 h p.i. the villi appeared normal.
E W Gray; K W Angus; D R Snodgrass
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general virology     Volume:  49     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-82     Citation Subset:  IM    
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MeSH Terms
Intestine, Small / microbiology,  ultrastructure*
Mamastrovirus / ultrastructure*
Microscopy, Electron
Sheep Diseases / microbiology,  pathology*
Virus Diseases / microbiology,  pathology,  veterinary*
Viruses, Unclassified / ultrastructure*

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