Document Detail

Ultrastructure of parathyroid glands in triamcinolone-treated mice.
MedLine Citation:
PMID:  649497     Owner:  NLM     Status:  MEDLINE    
6 weeks old ICR strain mice were given 21 daily injections of the synthetic glucocorticoid, triamcinolone diacetate (8 mg/kg body weight) and their parathyroid glands were examined by light and electron microscopy and compared with untreated litter-mate controls. Parathyroid glands are composed of a single basic cell type, but some cells are electron-dense ('dark' cells) and some less dense ('light' cells). There is considerable variability in numbers of light and dark cells from gland to gland. Following triamcinolone treatment the cells are arranged more in whorls, and there is a relative increase in the numbers of 'light' cells, which become more elongated, with pronounced nucleoli, and develop in many cases marked cytoplamsic vacuolation. Some cells show accumulations of lipid droplets. Interdigitations between adjacent cells become more complex, and the numbers of atrophic cells increase. The significance of the various cell conditions is considered. The ultrastructural appearances suggest that parathyroid gland cellular activity is stimulated in response to the drug-induced hypercorticoidism, but no overall glandular hypertrophy is found.
R Coleman; M Silbermann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of anatomy     Volume:  126     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-92     Citation Subset:  IM    
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MeSH Terms
Mice, Inbred ICR
Microscopy, Electron
Parathyroid Glands / drug effects*,  ultrastructure
Triamcinolone / pharmacology*
Vacuoles / ultrastructure
Reg. No./Substance:

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