Document Detail

Ultrastructure of normal and neoplastic exocrine pancreas in the mummichog, Fundulus heteroclitus.
MedLine Citation:
PMID:  7817116     Owner:  NLM     Status:  MEDLINE    
The ultrastructure of exocrine pancreatic neoplasms occurring in the mummichog, Fundulus heteroclitus, from a creosote-contaminated site in the Elizabeth River, Virginia, is described and related to nonneoplastic exocrine pancreas. Normal mummichog pancreas was an anastomosing tubular gland, with parenchymal cells organized as branched, anastomosing tubules around a central ductular system. The pancreatic ductular system consisted sequentially of terminal canalicular lumens lined by acinar cells, pancreatic preductules formed by an acinar and a centroductular cell, pancreatic ductules lined by 2 centroductular cells, and pancreatic ducts lined by cuboidal or columnar epithelial cells resting on a basal lamina and stromal sheath. Acinar cell adenomas retained the normal tubular organization and relationship between acinar and centroductular cells. Tumor cells exhibited nuclear pleomorphism but contained a full complement of normal zymogen granules and rough endoplasmic reticulum (RER). Some adenomas exhibited necrosis and cellular degeneration. Acinar cell carcinomas ranged from well to poorly differentiated. They exhibited loss of cell polarity, moderate to severe nuclear pleomorphism, extensive variation in size, shape, and number of zymogen granules, variability in RER content, and cellular degeneration. Acinar cell neoplasms in the mummichog were similar to those induced chemically in other fishes and certain mammals, suggesting that this fish population has been exposed to potent chemical carcinogens and that the species may be an effective indicator of polluted estuarine environments.
W K Vogelbein; J W Fournie
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Toxicologic pathology     Volume:  22     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1995-02-03     Completed Date:  1995-02-03     Revised Date:  2009-07-01    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  248-60     Citation Subset:  IM    
School of Marine Science, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point 23062.
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MeSH Terms
Adenoma / ultrastructure,  veterinary
Carcinoma, Acinar Cell / ultrastructure,  veterinary
Fish Diseases / pathology*
Killifishes / anatomy & histology*
Microscopy, Electron / veterinary
Pancreas / ultrastructure*
Pancreatic Neoplasms / ultrastructure,  veterinary*

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